A critical literature review of health economic evaluations of rotavirus vaccination

Aballéa, Samuel; Millier, A.; Quilici, S; Caroll, Stuart; Petrou, Stavros; Toumi, Mondher

doi:10.4161/hv.24253

Cited by 38 publications

(29 citation statements)

References 105 publications

(143 reference statements)

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“…Over 100 hundred studies evaluating the cost-effectiveness of rotavirus vaccination have been conducted, but nearly all studies have focused on the direct and indirect cost of illness, and very few have considered QOL 173 . Although providing a single global estimate of the cost-effectiveness of vaccinations is difficult, one analysis of the economic impact of rotavirus vaccination in eligible countries by Gavi, the Vaccine Alliance, reported a cost-effectiveness of US$42 per disability-adjusted life year averted.…”

Section: Quality Of Lifementioning

confidence: 99%

Rotavirus infection

Crawford

Ramani

Tate

et al. 2017

Nat Rev Dis Primers

524

558

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Rotavirus infections are a leading cause of severe, dehydrating gastroenteritis in children <5 years of age. Despite the global introduction of vaccinations for rotavirus over a decade ago, rotavirus infections still result in >200,000 deaths annually, mostly in low-income countries. Rotavirus primarily infects enterocytes and induces diarrhoea through the destruction of absorptive enterocytes (leading to malabsorption), intestinal secretion stimulated by rotavirus non-structural protein 4 and activation of the enteric nervous system. In addition, rotavirus infections can lead to antigenaemia (which is associated with more severe manifestations of acute gastroenteritis) and viraemia, and rotavirus can replicate in systemic sites, although this is limited. Reinfections with rotavirus are common throughout life, although the disease severity is reduced with repeat infections. The immune correlates of protection against rotavirus reinfection and recovery from infection are poorly understood, although rotavirus-specific immunoglobulin A has a role in both aspects. The management of rotavirus infection focuses on the prevention and treatment of dehydration, although the use of antiviral and anti-emetic drugs can be indicated in some cases.

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Section: Quality Of Lifementioning

confidence: 99%

Rotavirus infection

Crawford

Ramani

Tate

et al. 2017

Nat Rev Dis Primers

524

558

View full text Add to dashboard Cite

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“…La gravité et la mortalité de la maladie sont cependant majorées dans les pays à revenus faibles d'Afrique subsaharienne et d'Asie du Sud, dans lesquelles 94% des décès sont enregistrés (Parashar et al, 2006). À ce jour, la vaccination est la meilleure stratégie de lutte contre le rotavirus, et sa mise en oeuvre a été recommandée par l'Organisation Mondiale de la Santé (Aballéa et al, 2013).…”

Section: Introductionunclassified

Epidémiologie moléculaire du rotavirus du groupe A associé aux gastroentérites chez les enfants de moins de 5 ans dans la ville de Yaoundé (Cameroun)

Eteme¹,

Ntungwen²,

Fohouo³

et al. 2016

Int. J. Bio. Chem. Sci

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RESUMELe rotavirus est la première cause de gastroentérites grave chez les enfants de moins de 5 ans. La gravité et la mortalité de la maladie sont majorées dans les pays à revenus faibles d'Asie du sud et d'Afrique subsaharienne. Au Cameroun, la forte prévalence des rotaviroses, associées aux spécificités génotypiques locales du virus, soulignent l'importance de disposer de données épidémiologiques sur le virus. Cette étude visait à contribuer à une meilleure connaissance des principales souches de rotavirus responsables des gastroentérites chez les enfants de moins de 5 ans dans la ville de Yaoundé. Il s'agit d'une étude descriptive transversale d'une durée de 4 mois, dans 8 formations sanitaires de la ville de Yaoundé. Les échantillons de selles d'enfants de moins de 5 ans, hospitalisés pour gastroentérite ont été prélevés. La recherche du rotavirus s'est faite avec le kit ELISA Oxoid ProSpec TTM, et la détermination des génotypes du virus s'est faite par RT -PCR. Cent trente échantillons de selles d'enfants souffrant de gastroentérite ont été collectés. 66,1% de ces échantillons provenaient des hôpitaux FCB/CME, du CHE et de HDE. Le rotavirus a été isolé chez 30% des enfants, dont 40% avait entre 6 et 11 mois. Le CHE (6,9%) et l'HGY (0%) avaient respectivement la prévalence la plus élevée et la plus basse de la ville. Un nombre élevé de combinaisons génotypiques a été isolé, parmi lesquels prédominaient G1P [8] ABSTRACTRotavirus is the leading cause of severe gastroenteritis in children less than 5 years. Severity and mortality of this disease are majored in low-income countries of South -Asia and sub -Saharan Africa. In Cameroon, the high prevalence of rotaviruses associated to local genotypic specificities of virus enhances the importance of epidemiological database on the virus. This study aimed at contributing to a better knowledge of the main rotavirus strains responsible for gastroenteritis in children less than 5 years in Yaoundé. We carried out a descriptive and cross sectional study during 4 months, in 8 health centers in Yaoundé. Stool specimens were collected from children less than 5 years old, hospitalized for gastroenteritis. Rotavirus was detected with ELISA kit Oxoid ProSpecT TM , and genotypes determined by RT -PCR. One hundred and twenty seven stool specimens were collected during the study. FCB/CME, CHE, HDE provided 66.1% of specimens collected. Rotavirus was isolated in 30% of children, and 40% of these children were between 6 to 11 months old. The CHE (6. 9%) and the HGY (0%) had respectively the highest and the lowest prevalence of the town. A large number of genotype has been isolated and G1P[8] (31%) were predominant, followed by G3P [6]

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“…One reason for the decision of many countries not to include RV vaccination in their NIP is that the cost-effectiveness of such vaccinations is controversial. 10 Part of the reason for the controversy about the cost-effectiveness of RV vaccination is that the available information about the epidemiology and actual burden of RV disease is rather limited in many countries.…”

Section: Introductionmentioning

confidence: 99%