A critical evaluation of nemolizumab for prurigo nodularis

Brooks, Sarah G.; Yosipovitch, Gil

doi:10.1080/1744666x.2024.2306225

Cited by 1 publication

(1 citation statement)

References 56 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This study observed a significant reduction in the diversity indices in lesional skin of AD patients compared to the non-lesional skin of AD and HCs, suggesting a less diverse bacterial community in AD, which is consistent with previous findings [11,12]. The significant reduction in microbial diversity, particularly in the lesional skin of the AD patients, underscores the critical role of the skin microbiome in maintaining cutaneous health and its potential disruption in disease states.…”

Section: Discussionsupporting

confidence: 91%

Investigating Distinct Skin Microbial Communities and Skin Metabolome Profiles in Atopic Dermatitis

Kim,

Cho,

Jung

et al. 2024

IJMS

View full text Add to dashboard Cite

Atopic dermatitis (AD) is a chronic inflammatory skin disorder influenced by genetic predisposition, environmental factors, immune dysregulation, and skin barrier dysfunction. The skin microbiome and metabolome play crucial roles in modulating the skin’s immune environment and integrity. However, their specific contributions to AD remain unclear. We aimed to investigate the distinct skin microbial communities and skin metabolic compounds in AD patients compared to healthy controls (HCs). Seven patients with AD patients and seven HCs were enrolled, from whom skin samples were obtained for examination. The study involved 16S rRNA metagenomic sequencing and bioinformatics analysis as well as the use of gas chromatography time-of-flight mass spectrometry (GC-TOF-MS) to detect metabolites associated with AD in the skin. We observed significant differences in microbial diversity between lesional and non-lesional skin of AD patients and HCs. Staphylococcus overgrowth was prominent in AD lesions, while Cutibacterium levels were decreased. Metabolomic analysis revealed elevated levels of several metabolites, including hypoxanthine and glycerol-3-phosphate in AD lesions, indicating perturbations in purine metabolism and energy production pathways. Moreover, we found a positive correlation between hypoxanthine and glycerol-3-phosphate and clinical severity of AD and Staphylococcus overgrowth. These findings suggest potential biomarkers for monitoring AD severity. Further research is needed to elucidate the causal relationships between microbial dysbiosis, metabolic alterations, and AD progression, paving the way for targeted therapeutic interventions.

show abstract

Section: Discussionsupporting

confidence: 91%