A critical assessment of some biomarker approaches linked with dietary intake

Crews, Helen M.; Alink, G.M.; Andersen, Rikke; Braesco, Véronique; Holst, Birgit; Maiani, Giuseppe; Ovesen, Lars; Scotter, Michael J.; Solfrizzo, Michele; Berg, R. van den; Verhagen, Hans; Williamson, Gary

doi:10.1079/bjn2001337

Cited by 83 publications

(62 citation statements)

References 255 publications

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“…The extent and efficiency of metabolism, including the proportion of the ingested carotenoid affected in this way, is not entirely clear. Therefore, serum levels of provitamin A carotenoids may only partially reflect their dietary intake (Crews et al, 2001).…”

Section: Carotenoidsmentioning

confidence: 99%

Validation of a food-frequency questionnaire assessment of carotenoid and vitamin E intake using weighed food records and plasma biomarkers: The method of triads model

et al. 2004

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Background: Reliability or validity studies are important for the evaluation of measurement error in dietary assessment methods. An approach to validation known as the method of triads uses triangulation techniques to calculate the validity coefficient of a food-frequency questionnaire (FFQ). Objective: To assess the validity of an FFQ estimates of carotenoid and vitamin E intake against serum biomarker measurements and weighed food records (WFRs), by applying the method of triads. Design: The study population was a sub-sample of adult participants in a randomised controlled trial of b-carotene and sunscreen in the prevention of skin cancer. Dietary intake was assessed by a self-administered FFQ and a WFR. Nonfasting blood samples were collected and plasma analysed for five carotenoids (a-carotene, b-carotene, b-cryptoxanthin, lutein, lycopene) and vitamin E. Correlation coefficients were calculated between each of the dietary methods and the validity coefficient was calculated using the method of triads. The 95% confidence intervals for the validity coefficients were estimated using bootstrap sampling. Results: The validity coefficients of the FFQ were highest for a-carotene (0.85) and lycopene (0.62), followed by b-carotene (0.55) and total carotenoids (0.55), while the lowest validity coefficient was for lutein (0.19). The method of triads could not be used for b-cryptoxanthin and vitamin E, as one of the three underlying correlations was negative. Conclusions: Results were similar to other studies of validity using biomarkers and the method of triads. For many dietary factors, the upper limit of the validity coefficients was less than 0.5 and therefore only strong relationships between dietary exposure and disease will be detected.

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Section: Carotenoidsmentioning

confidence: 99%

Validation of a food-frequency questionnaire assessment of carotenoid and vitamin E intake using weighed food records and plasma biomarkers: The method of triads model

et al. 2004

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“…Although biologic assessment of blood, adipose tissue, urine, stool or other biologic material is often used effectively as an objective marker of dietary exposures, no established biomarker currently exists for total fat intake. Biomarkers of dietary intake are not the total answer and most available markers are subject to marked interindividual variation, and often reflect only recent intakes; quantification may also be extremely complex (Crews et al, 2001).…”

Section: Fatmentioning

confidence: 99%

Diet and cancer prevention

2004

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Dietary effects are presumed to underlie many of the large international differences in incidence seen for most cancers. Apart from alcohol and a few micronutrients, however, the role of specific nutritional factors remains illdefined. The evidence for a role of energy balance, physical inactivity, and obesity has strengthened, while for dietary fat it has weakened. Phytochemicals such as folate, lycopene and flavonoids are still the subject of active research. As the mechanisms underlying human carcinogenesis are better understood, dietary research will focus increasingly on intermediate markers such as the insulin-like growth factors and potentially carcinogenic metabolites.

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“…Biomarkers of intake have the advantage of not being reliant on the subject's memory or on the accuracy of recording food intake, and they are not dependent on the accuracy of food data tables (Crews et al, 2001). Ideally, biomarkers should be specific and sensitive, and they should not be too invasive for human studies.…”

Section: Discussionmentioning

confidence: 99%

The use of biomarkers in multicentric studies with particular consideration of iodine, sodium, iron, folate and vitamin D

Ovesen

Boeing

2002

Eur J Clin Nutr

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Objective: To determine which biomarkers should be used in a European monitoring system to assess intake of iodine, sodium, iron, folate and vitamin D. These nutrients are relevant for human health but difficult to assess in the diet in a comparable way among countries. Results: Iodine and sodium are mainly excreted in urine. Mean population intakes of iodine and sodium can be estimated by casual urine samples. However, habitual individual intake assessments require multiple 24 h urine collections. Serum ferritin is a sensitive test of iron status (mobilizable storage iron) and continues to be the leading single determination for individual iron status, but with serum transferrin receptor as a promising alternative because it is more specific than ferritin. Erythrocyte folate and homocysteine in blood are markers of folate status which are able to discriminate between normal status and levels of insufficiency in an individual. Serum 25-hydroxyvitamin D is a good marker for vitamin D deficiency in the individual, and can distinguish between overt deficiency and marginal deficiency, especially if combined with serum parathyroid hormone. Conclusions: Specific and sensitive markers for the dietary intake of iodine, sodium, iron, folate and vitamin D are available, which have the advantage of being more accurate than intake estimations derived from dietary surveys. However, the use of biomarkers also has disadvantages such as extra burden in terms of logistics, budget and ethical approval, and can moreover reduce the participation rate. More basic data for the validity of cross-country comparisons are needed and ideas in terms of study design and sampling frame.

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A critical assessment of some biomarker approaches linked with dietary intake

Cited by 83 publications

References 255 publications

Validation of a food-frequency questionnaire assessment of carotenoid and vitamin E intake using weighed food records and plasma biomarkers: The method of triads model

Validation of a food-frequency questionnaire assessment of carotenoid and vitamin E intake using weighed food records and plasma biomarkers: The method of triads model

Diet and cancer prevention

The use of biomarkers in multicentric studies with particular consideration of iodine, sodium, iron, folate and vitamin D

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