2019
DOI: 10.1038/s41598-019-44606-4
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A critical analysis of Powell’s results on the interdivision time distribution

Abstract: The cell-age and interdivision-time probability density functions (PDFs) have been extensively investigated since the 1940s due to their fundamental role in cell growth. The pioneering work of Powell established the first relationship between the interdivision-time and cell-age PDFs. In the literature, two definitions for the interdivision-time PDF have been proposed. One stands for the age-at-rupture PDF and is experimentally observable, whereas the other is the probability density that a cell divides at a ce… Show more

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Cited by 2 publications
(1 citation statement)
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“…( 21 ) is not the most general way to obtain the quantities referring to the whole cell population from those referring to a single cell line. A more general approach would involve other model parameters being random variables (e.g., cell volume, cell cycle length), so that the age structure or the Master equation for protein levels would be derived ’from scratch’ from the time evolution of these variables 28 30 .…”
Section: Modelmentioning
confidence: 99%
“…( 21 ) is not the most general way to obtain the quantities referring to the whole cell population from those referring to a single cell line. A more general approach would involve other model parameters being random variables (e.g., cell volume, cell cycle length), so that the age structure or the Master equation for protein levels would be derived ’from scratch’ from the time evolution of these variables 28 30 .…”
Section: Modelmentioning
confidence: 99%