A Crazy Cause of Crazy Paving: An Unusual Case of Amiodarone Induced Lung Toxicity

Mahmoud, Omar; Ishikawa, O.; Gabra, Nader Ishak; Altschul, Erica; Oron, Maly; Shah, Varun; Mina, Bushra

doi:10.1016/j.chest.2019.08.1103

Cited by 2 publications

(3 citation statements)

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“…Symptoms may be absent or include a nonproductive cough, dyspnea, weight loss, fever, and pleuritic chest pain [ 2 , 3 , 6 ]. In this case, the patient had nonspecific symptoms compatible with the findings described in the literature.…”

Section: Discussionmentioning

confidence: 99%

“…Pulmonary involvement can present in various ways, including, interstitial pneumonitis with different degrees of fibrosis, eosinophilic pneumonia, organizing pneumonia, diffuse alveolar hemorrhage, ARDS, pulmonary masses or nodules, and, rarely, pleural disease, and exudative pleural effusions isolated or occur in association with interstitial pneumonitis [ 1 – 3 , 6 , 7 ]. Interstitial pneumonitis is the most common presentation of amiodarone-induced lung toxicity, and appears after 2 or more months of therapy [ 1 , 2 ].…”

Section: Discussionmentioning

confidence: 99%

“…Interstitial pneumonitis is the most common presentation of amiodarone-induced lung toxicity, and appears after 2 or more months of therapy [ 1 , 2 ]. Amiodarone-induced pulmonary toxicity can be found unilaterally [ 6 ].…”

Section: Discussionmentioning

confidence: 99%

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From the Heart to the Lung: A Case of Drug Toxicity

et al. 2021

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Patient: Female, 71-year-old Final Diagnosis: Drug toxicity Symptoms: Dry cough • dyspnea Medication: — Clinical Procedure: Drug withdrawal Specialty: Pulmonology Objective: Unusual clinical course Background: Amiodarone is an anti-arrthymic drug used to treat and prevent several types of dysrhythmias. This drug is known for multiple-organ toxicity. Lung toxicity occurs in about 1% to 5% of cases. A wide variety of lung manifestations have been described, from mild to severe forms. Pulmonary toxicity can be acute, sub-acute, or chronic. Amiodarone-induced lung toxicity is a diagnosis of exclusion. The main treatment is discontinuation of the drug. Lung disease may progress initially due to the prolonged half-life and the accumulation of amiodarone in adipose tissue. Regarding the prognosis, lung toxicity can be reversible, but in some cases, it is irreversible and is sometimes fatal. The risks associated with its use must always be considered. Amiodarone should only be used for short periods. Case Report: The authors present a case of a 71-year-old female patient, taking amiodarone 200 mg/day for 18 months. The patient presented with amiodarone-induced lung toxicity. After drug withdrawal, without corticosteroid therapy, we observed clinical, functional, and radiological improvement. Conclusions: This case shows that not all cases of amiodarone-induced lung toxicity require corticosteroid therapy, and highlights that is important to consider this diagnosis in patients on amiodarone therapy with respiratory symptoms.

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Section: Discussionmentioning

confidence: 99%