A coupled computational framework for bone fracture healing and long‐term remodelling: Investigating the role of internal fixation on bone fractures

Quinn, Conall; Kopp, Alexander; Vaughan, Ted J.

doi:10.1002/cnm.3609

Cited by 7 publications

(5 citation statements)

References 53 publications

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“…While E is reduced from 110 to 100 GPa, the healing performance increases from .126 to .131, the difference of which is only .005. Although smaller E can make H at the 120th higher, Quinn et al 52 have found that even though there is no bone plate fixation, the formation of a bony bridge can still occur under reasonable load conditions. When fixing the fracture, the most important things are to achieve effective reduction and maintain a certain fixation stability.…”

Section: Resultsmentioning

confidence: 99%

The optimal design of 3D‐printed lattice bone plate by considering fracture healing mechanism

Ding

Xiong

et al. 2023

Numer Methods Biomed Eng

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The biomechanical stimulus is the most important factor for fracture healing and mainly determined by the structural stiffness of bone plate. Currently, the materials commonly used in bone plates are stainless steel and titanium, which often lead to stress shielding effects because of their higher elastic modulus compared with the bone. This article suggests an optimal design method of lattice bone plate based on fracture healing theory. First, the mechanical regulation model with deviatoric strain is established to simulate the tissue differentiation process during fracture healing process. The ratio of the average elastic modulus of callus at the 120th day to the elastic modulus of mature bone is used to characterize the fracture healing rate. Second, the optimal elastic modulus of the design domain is obtained by the optimization mathematical model with the maximum fracture healing rate. Then, the design domain is filled with microstructures, the porosity of which is adjusted to make it possible that the equivalent elastic modulus is equal to the optimized value. And the finite element analysis of the bone plate with microstructure is executed. Finally, the designed lattice bone plates are manufactured through 3D printing, and the mechanical test is carried out. The simulation results indicate that the fracture healing rate is maximum when the elastic modulus of material in design domain is 38 GPa under the constraints of fixation stability. And both the finite element analysis and experiment results show that the designed lattice bone plate meet the strength requirements of fracture internal fixation implants.

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Section: Resultsmentioning

confidence: 99%

The optimal design of 3D‐printed lattice bone plate by considering fracture healing mechanism

Ding

Xiong

et al. 2023

Numer Methods Biomed Eng

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“…It is assumed that the mesenchymal stem cells origin from the surrounding tissues, periosteum and trabecular bone ( Fig 2 ). In order to avoid too fast stiffening of the regions next to the callus borders, similarly as in [ 42 ], the concentration at the boundaries varies in time such that the maximum value is reached after ca. 3 weeks c bound = 1.0− exp (− t /4) [days], (see Fig 2 ).…”

Section: Methodsmentioning

confidence: 99%

“…Moreover, it has to be emphasized, that usually in studies employing similar finite element model (FEM) [ 33 , 42 ], the poroelastic tissues are considered as fully saturated. However, in the present study a partial saturation is assumed to account for the capillary effects.…”

Section: Methodsmentioning

confidence: 99%

Comparative analysis of mechanical conditions in bone union following first metatarsophalangeal joint arthrodesis with varied locking plate positions: A finite element analysis

Sabik,

Daszkiewicz,

Witkowski

et al. 2024

PLoS ONE

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Background First metatarsophalangeal joint arthrodesis is a typical medical treatment performed in cases of arthritis or joint deformity. The gold standard for this procedure is arthrodesis stabilisation with the dorsally positioned plate. However, according to the authors’ previous studies, medially positioned plate provides greater bending stiffness. It is worth to compare the mechanical conditions for bone formation in the fracture callus for both placements of the locking plate. Methods Two finite element models of the first metatarsophalangeal joint with the dorsally and medially positioned plate were defined in the Abaqus software to simulate differentiation of the fracture callus. A simplified load application, i.e. one single step per each day and the diffusion of the mesenchymal stem cells into the fracture region were assumed in an iterative hardening process. The changes of the mesenchymal stem cells into different phenotypes during the callus stiffening were governed by the octahedral shear strain and interstitial fluid velocity according to Prendergast mechanoregulation theory. Basing on the obtained results the progress of the cartilage and bone tissues formation and their distribution within the callus were compared between two models. Findings The obtained results suggest that after 6 weeks of simulation the healing progress is in general comparable for both plates. However, earlier closing of external callus was observed for the medially positioned plate which had greater vertical bending stiffness. This process enables faster internal callus hardening and promotes symmetrical bridging.

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“…Weight and bulk [28] Metallic bone plates can add weight and bulk to the surgical construct, which can be a concern in certain cases, particularly for pediatric patients or when implants are used in weight-bearing areas.…”

Section: Exploration Of Innovative Techniques and Materialsmentioning

confidence: 99%

A novel carbon‐flax bioepoxy hybrid composite bone plate with enhanced bio‐mechanical performance

Kennedy,

Arunachalam,

Kannan

2024

Materialwissenschaft Werkst

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This study aimed to pioneer a transformative approach in orthopedic implant design by developing and analyzing a groundbreaking carbon‐flax reinforced bioepoxy hybrid composite bone plate. The primary objectives of the present research were to enhance the bio‐mechanical performance of orthopedic implants and explore the potential applications of the novel material for orthopedic implants. Hybrid composite plate was fabricated mimicking the human bone with the soft inner core and a rigid outer coating. Mechanical properties for the hybrid composite were obtained through material characterization studies as per ASTM standards. The hybrid composite bone plates were tested as per bio‐mechanical test standard and the results were correlated with the finite element simulations. The maximum stress value in the experiments for the biomechanical four‐point bending tests was 331.74 MPa, and the corresponding strain value was 0.0337. The maximum equivalent stress and strain values obtained from simulation were in line with the findings of the experiments. The current research signifies a paradigm shift in orthopedic implant technology. The carbon‐flax bioepoxy hybrid composite offers remarkable potential for orthopedic applications, promising safer and more durable solutions for patients in need of bone repair or replacement.

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A coupled computational framework for bone fracture healing and long‐term remodelling: Investigating the role of internal fixation on bone fractures

Cited by 7 publications

References 53 publications

The optimal design of 3D‐printed lattice bone plate by considering fracture healing mechanism

The optimal design of 3D‐printed lattice bone plate by considering fracture healing mechanism

Comparative analysis of mechanical conditions in bone union following first metatarsophalangeal joint arthrodesis with varied locking plate positions: A finite element analysis

A novel carbon‐flax bioepoxy hybrid composite bone plate with enhanced bio‐mechanical performance

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