A Cost-Utility Analysis of 5 Strategies for the Management of Acute Otitis Media in Children

Shaikh, Nader; Dando, Emily; Dunleavy, Mark L.; Curran, Dorothy; Martin, Judith M.; Hoberman, Alejandro

doi:10.1016/j.jpeds.2017.05.047

Cited by 26 publications

(18 citation statements)

References 27 publications

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“…Rather than using these data, we used data from our prospective, randomized trial in which the number of children with resistant organisms did not differ between the antibiotic and placebo groups at the final study visit. 1 Second, they raise concern that, contrary to the study by Bezáková et al, we did not consider the long-term effects (>30 days) of antibiotics on recurrent AOM. 3 To our knowledge, all long-term studies to date [4][5][6] have uniformly failed to demonstrate differences in the rate of recurrent AOM in children randomized to antibiotics compared with placebo.…”

Section: Replymentioning

confidence: 76%

The long-term effects of direct amoxicillin in acute otitis media

Broekhoven

Plötz

2018

The Journal of Pediatrics

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Section: Replymentioning

confidence: 76%

The long-term effects of direct amoxicillin in acute otitis media

Broekhoven

Plötz

2018

The Journal of Pediatrics

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“…The estimation of the costs of the disease is an important tool for decision-making, as well as a useful input for performing complete economic evaluations of cost-effectiveness and cost-utility, as it has been done in other countries (28,29).…”

Section: Discussionmentioning

confidence: 99%

Costs of acute otitis media in children in a city of the Colombian Caribbean coast

et al. 2019

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Introduction: Acute otitis media is the main cause of consultation, antibiotic use, and ambulatory surgery in developed countries; besides, it is associated with an important economic burden. However, non-medical indirect costs of acute otitis media, which are relevant in this pathology, have been underestimated.Objective: To estimate the costs of acute otitis media in pediatric patients in Cartagena, Colombia.Materials and methods: We conducted a prospective study of micro-costing between 2014 and 2015. The direct and indirect costs of acute otitis media were determined through forms applied to parents or caregivers. Loss of productivity was estimated based on the monthly legal minimum wage of 2014 (COP $616.000) (USD $308).Results: A total of 62 episodes of acute otitis media occurred. The total economic costs attributed per episode was COP $358,954 (standard deviation: SD ± COP $254,903, i.e., USD $179). The total economic burden was COP $22,503,141 (USD $11,250), the indirect costs per episode were COP $101,402 (USD $51), and the average care time spent by parents was 3.7 days.Conclusion: The estimated costs of acute otitis media in this study were lower than the costs estimated in a review of high-income countries and similar to those of low-income countries such as Nigeria. Information on total costs (direct and indirect) of acute otitis media is necessary for public health decision-making and for full cost-effectiveness assessments.

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“…The use of broader‐spectrum antibiotics also increases the likelihood of adverse events, including increased duration of hospitalization and higher healthcare costs . An inpatient evaluation of 252 subjects with beta‐lactam antibiotic allergy on their charts found that evaluation (and de‐labelling in 90.5% of these patients) prevented 504 inpatient days and 648 outpatient days on alternative antibiotics .…”

Section: The Necessity Of Ruling Out Amoxicillin Allergy In Childrenmentioning

confidence: 99%

Should testing be initiated prior to amoxicillin challenge in children?

Abrams

Ben‐Shoshan

2019

Clin Experimental Allergy

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Amoxicillin is the most common antibiotic prescribed in children with increasing use over time. While up to 10% of children are labelled as amoxicillin allergic, most children can tolerate amoxicillin after allergy evaluation. It is well documented that the label of amoxicillin allergy in children is associated with adverse health outcomes such as antibiotic-resistant infections. However, it remains controversial how best to assess children for amoxicillin allergy. While in general it is recommended that skin testing be done prior to drug provocation test in the evaluation of amoxicillin allergy, there is increasing evidence that drug provocation testing could be done in lower risk children without skin testing prior. The goal of this article as a narrative review is to review the strengths and limitations of skin testing prior to drug provocation test in children who have a history of either immediate or non-immediate, reactions to amoxicillin. K E Y W O R D Sanaphylaxis, drug allergy, immunologic tests

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A Cost-Utility Analysis of 5 Strategies for the Management of Acute Otitis Media in Children

Cited by 26 publications

References 27 publications

The long-term effects of direct amoxicillin in acute otitis media

The long-term effects of direct amoxicillin in acute otitis media

Costs of acute otitis media in children in a city of the Colombian Caribbean coast

Should testing be initiated prior to amoxicillin challenge in children?

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