A Cost-Effective Way to Produce Gram-Scale ¹⁸O-Labeled Aromatic Aldehydes

Abstract

Obtaining 18O-labeled organic substances is of great research importance and also an extremely challenging work. In this work, depending on the reversed Knoevenagel reaction, 18O-labeled aromatic aldehydes (3a–3x) are successfully obtained with high total yields (52–72%) and sufficient 18O abundance (90.90–96.09%).

Synthesis and Spectroscopic Characterization of Furan-2-Carbaldehyde-d

“…Hence, deuteration is an important research issue in medicinal chemistry as well [10,11]. In addition, 2 H-, and even 14 C-and 18 Oisotope derivatives of furfural, especially of the aldehyde group, have been synthesized before [10,12]. As early as 1973, D.J.…”

Electrochemical Synthesis of 5‐Benzylidenebarbiturate Derivatives and Their Application as Colorimetric Cyanide Probe

“…Different conditions and solvents were reported in the literature for this reaction, however, many of them required long reaction time and/or expensive catalysts. Thus, various approaches for synthesis were reported: in methanol at room temperature for 12 h up to five days, [10] in refluxing ethanol for 4-12 h, [6,[11][12][13] in refluxing ethanol/piperidine/acetic acid for 4 h, [3] in refluxing ethanol/ piperidine for 5-10 h, [2] in aqueous NaOH solution for 12 h at room temperature, [5] in refluxing water for 2-12 h. [7,14,15] The reaction was reported in water using different catalysts such as L-tyrosine in 10 min. at room temperature, [1] and 2,2'-bipyridinium dihydrogen phosphate in 7-15 min at 70 °C.…”