A Cost-effective Method for Femoral Head Allograft Procurement for Spinal Arthrodesis

Brown, Desmond; Mallory, Grant W.; Higgins, Dominique; Abdulaziz, Mohammed; Huddleston, P.M.; Nassr, Ahmad; Fogelson, Jeremy L.; Clarke, Michelle J.

doi:10.1097/brs.0000000000000395

Cited by 8 publications

(7 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although autologous iliac crest bone remains the "gold standard," femoral-sourced grafts have been commonly used in spinal fusion and bone grafting procedures. In clinical fusion procedures, femoral ring and femoral dowel allografts have been widely employed as osteoconductive structural grafts in interbody procedures [29][30][31][32][33], while femoral head allograft has been successfully used in interbody [16,[34][35][36], and posterolateral lumbar procedures [15,17]. With increasing interest in the use of femoral reamer-irrigator-aspirator (RIA) bone autograft, a number of clinical studies have recently compared the efficacy of RIA and iliac crest autograft in nonunion, posttraumatic segmental bone defect, or ankle fusion patients and have observed comparable [37][38][39][40], or increased union rates and times to union [41].…”

Section: Discussionmentioning

confidence: 99%

“…The ability to employ syngeneic allografts also enables evaluation of the fusion efficacy of bone grafts derived from different skeletal sites. Remarkably, despite the widespread use of femoral-sourced allografts in clinical spinal fusion procedures and the increasing interest in using femoral reamer-irrigator-aspirator (RIA) autograft in clinical bone grafting procedures, the fusion efficacy of femoral-and iliac crest-derived grafts has yet to be compared in the spine [15][16][17][18]. In this study, we thus directly compared the use of autograft iliac crest bone to syngeneic femoral and iliac crest allograft bone in the rat model of posterolateral lumbar spinal fusion.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Comparing the efficacy of syngeneic iliac and femoral allografts with iliac crest autograft in a rat model of lumbar spinal fusion

et al. 2020

View full text Add to dashboard Cite

Background Despite widespread use of femoral-sourced allografts in clinical spinal fusion procedures and the increasing interest in using femoral reamer–irrigator–aspirator (RIA) autograft in clinical bone grafting, few studies have examined the efficacy of femoral grafts compared to iliac crest grafts in spinal fusion. The objective of this study was to directly compare the use of autologous iliac crest with syngeneic femoral and iliac allograft bone in the rat model of lumbar spinal fusion. Methods Single-level bilateral posterolateral intertransverse process lumbar spinal fusion surgery was performed on Lewis rats divided into three experimental groups: iliac crest autograft, syngeneic iliac crest allograft, and syngeneic femoral allograft bone. Eight weeks postoperatively, fusion was evaluated via microCT analysis, manual palpation, and histology. In vitro analysis of the colony-forming and osteogenic capacity of bone marrow cells derived from rat femurs and hips was also performed to determine whether there was a correlation with the fusion efficacy of these graft sources. Results Although no differences were observed between groups in CT fusion mass volumes, iliac allografts displayed an increased number of radiographically fused fusion masses and a higher rate of bilateral fusion via manual palpation. Histologically, hip-derived grafts showed better integration with host bone than femur derived ones, likely associated with the higher concentration of osteogenic progenitor cells observed in hip-derived bone marrow. Conclusions This study demonstrates the feasibility of using syngeneic allograft bone in place of autograft bone within inbred rat fusion models and highlights the need for further study of femoral-derived grafts in fusion.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Comparing the efficacy of syngeneic iliac and femoral allografts with iliac crest autograft in a rat model of lumbar spinal fusion

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Although autologous iliac crest bone remains the "gold standard", femoral-sourced grafts have been commonly used in spinal fusion and bone grafting procedures. In clinical fusion procedures, femoral ring and femoral dowel allografts have been widely employed as osteoconductive structural grafts in interbody procedures [29][30][31][32][33], while femoral head allograft has been successfully used in interbody [34][35][36][37], and posterolateral lumbar procedures [15,38]. With increasing interest in the use of femoral reamerirrigator-aspirator (RIA) bone autograft, a number of clinical studies have recently compared the e cacy of RIA and iliac crest autograft in nonunion, posttraumatic segmental bone defect, or ankle fusion patients and have observed comparable [39][40][41][42], or increased union rates and times to union [43].…”

Section: Discussionmentioning

confidence: 99%

“…The ability to employ syngeneic allografts also enables evaluation of the fusion e cacy of bone grafts derived from different skeletal sites. Remarkably, despite the widespread use of femoral-sourced allografts in clinical spinal fusion procedures and the increasing interest in using femoral reamer-irrigator-aspirator (RIA) autograft in clinical bone grafting procedures, the fusion e cacy of femoral-and iliac crest-derived grafts has yet to be compared in the spine [15][16][17][18]. In this study, we thus directly compared the use of autograft iliac crest bone to syngeneic femoral and iliac crest allograft bone in the rat model of posterolateral lumbar spinal fusion.…”

Section: Introductionmentioning

confidence: 99%

Comparing the Efficacy of Syngeneic Iliac and Femoral Allografts with Iliac Crest Autograft in a Rat Model of Lumbar Spinal Fusion

Holmes

Elder

Ishida

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: Despite widespread use of femoral-sourced allografts in clinical spinal fusion procedures and the increasing interest in using femoral reamer–irrigator–aspirator (RIA) autograft in clinical bone grafting, few studies have examined the efficacy of femoral grafts compared to iliac crest grafts in spinal fusion. The objective of this study was to directly compare the use of autologous iliac crest with syngeneic femoral and iliac allograft bone in the rat model of lumbar spinal fusion.Methods: Single-level bilateral posterolateral intertransverse process lumbar spinal fusion surgery was performed on Lewis rats divided into three experimental groups: iliac crest autograft; syngeneic iliac crest allograft; and syngeneic femoral allograft bone. Eight weeks postoperatively, fusion was evaluated via microCT analysis, manual palpation and histology. In vitro analysis of the colony-forming and osteogenic capacity of bone marrow cells derived from rat femurs and hips was also performed to determine whether there was a correlation with the fusion efficacy of these graft sources.Results: Although no differences were observed between groups in CT fusion rates or fusion mass volumes, iliac allografts displayed a higher rate of bilateral fusion via manual palpation. Histologically, hip-derived grafts showed better integration with host bone than femur derived ones, likely associated with the higher concentration of osteogenic progenitor cells observed in hip-derived bone marrow.Conclusions: This study demonstrates the feasibility of using syngeneic allograft bone in place of autograft bone within inbred rat fusion models and highlights the need for further study of femoral-derived grafts in fusion.

show abstract

“…The contralateral rod was loosened to ensure an excellent arthrodesis from the occipital bone to C-4 bilaterally using a femoral head allograft. 7 Rods were replaced, and the occipital C-2 region was compressed bilaterally, locking the fibular strut into place (Figs. 8 and 9).…”

Section: Stage 4: Posterior Tumor Removal and Spinal Column Reconstrumentioning

confidence: 99%

En bloc resection of a C-1 lateral mass osteosarcoma: technical note

Clarke¹,

Price²,

Cloft

et al. 2016

PED

Self Cite

View full text Add to dashboard Cite

Osteosarcoma is an aggressive primary bone tumor. It is currently treated with multimodality therapy including en bloc resection, which has been demonstrated to confer a survival benefit over intralesional resection. The authors present the case of an 8-year-old girl with a C-1 lateral mass osteosarcoma, which was treated with a 4-stage en bloc resection and spinal reconstruction. While technically complex, the feasibility of en bloc resection for spinal osteosarcoma should be explored in the pediatric population.

show abstract

A Cost-effective Method for Femoral Head Allograft Procurement for Spinal Arthrodesis

Abstract: N/A.

Cited by 8 publications

References 34 publications

Comparing the efficacy of syngeneic iliac and femoral allografts with iliac crest autograft in a rat model of lumbar spinal fusion

Comparing the efficacy of syngeneic iliac and femoral allografts with iliac crest autograft in a rat model of lumbar spinal fusion

Comparing the Efficacy of Syngeneic Iliac and Femoral Allografts with Iliac Crest Autograft in a Rat Model of Lumbar Spinal Fusion

En bloc resection of a C-1 lateral mass osteosarcoma: technical note

Contact Info

Product

Resources

About