A Cost‐Benefit Analysis of Prenatal Screening for Toxoplasmosis

Sahai, Vic; Onyett, Heather

doi:10.1155/1996/678145

Cited by 5 publications

(1 citation statement)

References 13 publications

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“…No cost-benefit analysis of neonatal screening in this cohort in Massachusetts and New Hampshire have been published, but studies in Europe and Canada have performed such analyses. Sahai and Onyett 23 studied prenatal screening in Canada and reported that at incidence rates even below the current estimates in Canada at the time, the cost of screening prenatally was easily justified when compared with the cost of long-term medical, social, and educational services for the patients and their families of those affected. European studies have concluded with a similar notion.…”

Section: Discussionmentioning

confidence: 99%

Atypical Bilateral Multifocal Congenital Toxoplasmosis Retinochoroiditis: Case Report With Literature Review

Reed

Agarwal-Sinha

2020

Journal of Investigative Medicine High Impact Case Reports

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Background Toxoplasmosis gondii is ubiquitously present on earth and infection, including congenital infection, is common. Neurological, developmental, and ocular effects can be devastating in the congenital toxoplasmosis population. At present, there is no standard, nation-wide neonatal screening for this disease in the United States. Case Presentation A 17-month-old Caucasian female presented to our institution by way of referral for macular scarring. She was diagnosed with intrauterine growth retardation and born with low birth weight and microcephaly at an outside institution, but no systemic workup was conducted at that time. On ocular examination, she was found to have nystagmus and extensive multifocal chorioretinal pigmented scars involving the macula and peripheral retina in both eyes with fibrous vitreous strands extending between scars in the right eye. Toxoplasmosis immunoglobulin G was found to be highly positive. Magnetic resonance imaging of the brain showed supratentorial intracranial calcifications. Conclusions Our patient presented with severe chorioretinal lesions, microcephaly, and nystagmus with a positive immunoglobulin G toxoplasmosis titer. She did not receive any evaluation, including TORCH infectious panel workup, on being born with low birth weight and microcephaly. There are currently no national programs in place for toxoplasmosis to be included in routine neonatal screening, despite the grave sequelae of congenital infection or that studies in other countries have shown cost-effectiveness in early screening and treatment.

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Section: Discussionmentioning

confidence: 99%

Atypical Bilateral Multifocal Congenital Toxoplasmosis Retinochoroiditis: Case Report With Literature Review

Reed

Agarwal-Sinha

2020

Journal of Investigative Medicine High Impact Case Reports

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Methodological limitations of economic evaluations of antenatal screening

Petrou

2001

Health Economics

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A review of recent economic studies of antenatal screening reveals widespread violation of accepted economic evaluation methodology. In particular, the costs and benefits of antenatal screening are often misclassified and conflated, and the non-resource effects of averted costs are often excluded from the evaluation process. The result is a widespread violation of the explicit and systematic approaches taken by economic analysts more generally, and conclusions that may be described as misleading. This letter calls for economic analysts to be consistent in their application of economic evaluation methodology to antenatal screening programmes.

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