A Cosolvency Model to Predict Solubility of Drugs at Several Temperatures from a Limited Number of Solubility Measurements.

Solubility of hydrophobic compounds in water–cosolvent mixtures: Relation of solubility with water–cosolvent interactions

“…Volume fraction seems to be more than just a practically convenient scale for expressing solvent composition when predicting solubility in mixed solvents. Different cosolvency models consistently include parameters that reflect the relative size of the solvents in the mixture, either implicitly (through the use of volume fraction concentrations) or explicitly (through the use of molar volumes13, 14). In our model, the product γ i x i is analogous to the product of a solubilizing intensity ( γ i ) and a solubilizing capacity ( f i ).…”

Estimation of the solubility with cosolvent composition by combinated of the Williams–Amidon model with quasi virial coefficient

“…There are several models, namely, the log‐linear (L‐L) model, the modified Wilson (MW) model, mixture response surface model, and the Williams–Amidon (WA) model, have been published in literatures to correlate the solubility of solute (s) in cosolvent + water mixtures. A deep reviewing of these models has been performed by Jouyban in “Handbook of Solubility of Pharmaceuticals.”…”

“…Based on the Wohl method of the excess Gibbs energy, Williams and Amidon derived a model, namely, the WA model, to predict the solubility of solute in solvent mixture and pure solvents, solvent–solvent interaction, and solute–solvent interaction . The two‐suffix of the WA model for binary solvent mixture is expressed as follows: …”

Prediction of Solubility of Drugs by Conductor-Like Screening Model for Real Solvents

“…The experimental data on the solubilities of drugs in the mixed solvent with different composition is sparse. Fortunately, excellent experimental data are available for oxolinic acid in water-ethanol system 7) and sulfadiazine in water-1,4-dioxane system.…”