A correlative study of adenomyosis and pelvic endometriosis, with special reference to the hormonal reaction of ectopic endometrium

Novak, Emil; Lima, Odair Alves de

doi:10.1016/0002-9378(48)90401-3

Cited by 43 publications

(11 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…21 Although progestins like medical oophorectomy were shown to be ideal methods for relieving symptoms related to endometriosis, they do lead to an incomplete suppression of endometriotic foci and there is a 5-year recurrence in up to 40% of patients. 22 The normal response of endometriotic tissue is unpredictable, and the specific mechanism whereby estrogens modulate cell proliferation is not fully understood.2 Recent studies have hypothesized that estrogens may act indirectly and directly: In the present study we did not find a uniform positivity in the immunohistochemical reaction for EGFr, ER and PR antisera for eutopic and ectopic endometrium. The endometriotic implants did not show immunostaining in several tissue samples, while a complete (100%) positivity was found when EGFr, ER, and PR antisera were used in the endometrium.…”

Section: Discussioncontrasting

confidence: 57%

Tissue Factors Influencing Growth and Maintenance of Endometriosis^a

Melega

Bulletti

et al. 1991

Annals of the New York Academy of Sciences

View full text Add to dashboard Cite

The unpredictable response of endometriosis to steroids and its recurrence after therapy, led us to hypothesize a possible further control of this pathology by factors other than steroids. The presence of estrogen, progesterone and epidermal growth factor receptors (ER, PR, EGFr) was evaluated using immunohistochemistry before and after therapy with Danazol or a gonadotropin-releasing hormone analogue (GnRHa), Buserelin. EGFr, ER and PR were present in 100% of endometrial specimens, and in 71%, 29% and 49% of endometriotic implants, respectively. Danazol and GnRHa reduced immunohistochemical staining for EGFr antisera in the endometrial and endometriotic specimens. About 21% of endometriosis were EGFr positive and ER negative, suggesting a potential role of epidermal growth factor in growth and maintenance of endometrial ectopia.

show abstract

Section: Discussioncontrasting

confidence: 57%

Tissue Factors Influencing Growth and Maintenance of Endometriosis^a

Melega

Bulletti

et al. 1991

Annals of the New York Academy of Sciences

View full text Add to dashboard Cite

show abstract

“…They stated: “since the ectopic endometrium reacts to ovarian hormones in exactly the same way as does the uterine mucosa, its histologic appearance permits an estimation of ovarian function, normal or otherwise.” This view was strongly opposed by Novak and de Lima [106], since there was no evidence of secretory changes in the ectopic endometrium in adenomyosis in the cases they examined, regardless of the phase of the cycle. They thus, concluded that the ectopic endometrium is of an immature type capable of responding to the effect of oestrogens but not to progesterone.…”

Section: Adenomyosis In Patients With Endometrial Cancermentioning

confidence: 71%

“…One possible explanation is the association between adenomyosis and pregnancy [106]. Pregnancy increases the risk of adenomyosis but may be protective against endometrial cancer [107].…”

Section: Adenomyosis In Patients With Endometrial Cancermentioning

confidence: 99%

Adenomyosis and Endometrial Cancer: Literature Review

Habiba

Pluchino

Petignat

et al. 2018

Gynecol Obstet Invest

View full text Add to dashboard Cite

To confirm the origin of cancer found in both the endometrium and the myometrium is difficult. Cancer may spread from the endometrium into adenomyotic foci or vice versa. Also, premalignant changes may arise at either or both sites. Investigating disease origin enhances our understanding of pathophysiology and prognosis. Additional critical questions are whether women with adenomyosis have a higher risk of endometrial cancer; whether the invasive properties and prognosis of cancer in adenomyosis differ from those arising in the eutopic endometrium and whether the ectopic glandular tissue in adenomyosis becomes altered in the presence of eutopic endometrial cancer. A final question is whether cancer arising within adenomyosis carries a worse prognosis because of its location within the myometrium and the possibility that the presence of adenomyosis facilitates invasion of cancer arising in the eutopic endometrium. The present review explores currently available literature in an attempt to answer these questions and to examine clinical presentations, diagnostic criteria, pathogenesis and prognosis.

show abstract

“…Although already in the 40s, Novak and de Lima [7] linked again adenomyosis and endometriosis, stating “one cannot resist the feeling that there is some common denominator between endometrial hyperplasia and adenomyosis, and possibly also pelvic endometriosis”, it was only over the last two decades that the search for the underlying link between endometriosis and adenomyosis received a major booster. The development that provided the first important lead was the introduction of magnetic resonance (MR) imaging; using this technique, the “myometrial junctional zone” (JZ) was identified as a functional uterine zone to form with the endometrium the endomyometrium unit [8].…”

Section: Historical Diagnostic Biasmentioning

confidence: 99%

Is adenomyosis the neglected phenotype of an endomyometrial dysfunction syndrome?

2011

View full text Add to dashboard Cite

Since the dissociation between adenomyoma and endometriosis in the 1920s and the laparoscopic progress in the diagnosis and surgery of endometriosis, the literature has been greatly focused on the disease endometriosis. The study of adenomyosis, on the other hand, has been neglected as the diagnosis remained based on hysterectomy specimens. However, since the introduction of magnetic resonance and sonographic imaging techniques in the 1980s, the myometrial junctional zone has been identified as a third uterine zone and interest in adenomyosis was renewed. This has also been the start for the interest in the role of the myometrial junctional zone dysfunction and adenomyosis in reproductive and obstetrical disorders.

show abstract

A correlative study of adenomyosis and pelvic endometriosis, with special reference to the hormonal reaction of ectopic endometrium

Cited by 43 publications

References 5 publications

Tissue Factors Influencing Growth and Maintenance of Endometriosis^a

Tissue Factors Influencing Growth and Maintenance of Endometriosis^a

Adenomyosis and Endometrial Cancer: Literature Review

Is adenomyosis the neglected phenotype of an endomyometrial dysfunction syndrome?

Contact Info

Product

Resources

About

A correlative study of adenomyosis and pelvic endometriosis, with special reference to the hormonal reaction of ectopic endometrium

Cited by 43 publications

References 5 publications

Tissue Factors Influencing Growth and Maintenance of Endometriosisa

Tissue Factors Influencing Growth and Maintenance of Endometriosisa

Adenomyosis and Endometrial Cancer: Literature Review

Is adenomyosis the neglected phenotype of an endomyometrial dysfunction syndrome?

Contact Info

Product

Resources

About

Tissue Factors Influencing Growth and Maintenance of Endometriosis^a

Tissue Factors Influencing Growth and Maintenance of Endometriosis^a