A correlation study between macro- and micro-analysis of pediatric urinary calculi

Abdel-Gawad, Mahmoud; Ali-El-Dein, Bedeir; Mehta, Sanjeev; Alkohlany, Khaled; Elsobky, Emad

doi:10.1016/j.jpurol.2014.06.022

Cited by 6 publications

(2 citation statements)

References 21 publications

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“…The mean values of the elemental content of human urinary calculi reported in 15 studies summarized in Table 1 are represented in rank order of the overall median values. Only values for calcium-based stones were analysed, apart from the data reported by Abdel-Gawad et al 176 in which 78% were calcium-based stones.…”

Section: Figurementioning

confidence: 99%

The elementome of calcium-based urinary stones and its role in urolithiasis

et al. 2015

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Urolithiasis affects around 10% of the US population with an increasing rate of prevalence, recurrence and penetrance. The causes for the formation of most urinary calculi remain poorly understood, but obtaining the chemical composition of these stones might help identify key aspects of this process and new targets for treatment. The majority of urinary stones are composed of calcium that is complexed in a crystalline matrix with organic and inorganic components. Surprisingly, mitigation of urolithiasis risk by altering calcium homeostasis has not been very effective. Thus, studies to identify other therapeutic stone-specific targets, using proteomics, metabolomics and microscopy techniques, have been conducted, revealing a high level of complexity. The data suggest that numerous metals other than calcium and many nonmetals are present within calculi at measurable levels and several have distinct distribution patterns. Manipulation of the levels of some of these elemental components of calcium-based stones has resulted in clinically beneficial changes in stone chemistry and rate of stone formation. The elementome—the full spectrum of elemental content—of calcium-based urinary calculi is emerging as a new concept in stone research that continues to provide important insights for improved understanding and prevention of urinary stone disease.

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Section: Figurementioning

confidence: 99%

The elementome of calcium-based urinary stones and its role in urolithiasis

et al. 2015

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“…However, taking into consideration that most of them are toxic, we can argue that the precipitation and accumulation of certain metals in the studied stones can be considered an efficient way to eliminate them from the human body. Metals in human stones are generally determined as their total concentration, in spite of the fact that their different chemical forms have different toxicity (Berry et al, 1985; Nuttall, 2006; Sarafanov et al, 2011; Giannossi et al, 2013; Abdel-Gawad et al, 2014). Therefore, a careful investigation of the metals associated with human stones by electron microprobe analyses, can be used to solve this problem.…”

Section: Summary and Concluding Remarksmentioning

confidence: 99%

Metals in Human Gall, Bladder, and Kidney Stones Based on an Electron Microprobe Investigation

Moser¹,

Zaccarini

Moser³

et al. 2015

Microsc Microanal

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Several particles of copper accompanied by a few particles of nickel, lead, and a compound composed of selenium containing minor Ni, Si, Cu, and Co were found in human gall, kidney, and bladder stones. The investigated particles occur as tiny grains, <10 µm in size, that are irregularly dispersed in the stones. Therefore, they were studied by scanning electron microscopy and qualitatively analyzed by energy dispersive system. One grain of copper contained a small amount of Ni and Zn, and some grains of nickel proved to contain Cr as trace element. Most of the discovered metals formed a single-phase grain. However, a few grains found in two gallstones were associated with inclusions of calcium and apatite. Based on the results presented in this contribution, we argue that most of the studied metals can be classified as endogenous particles, i.e., directly precipitated from the same fluids that formed their host human stones. This observation suggests that the precipitation and accumulation of metals in some human stones can be considered an efficient way to eliminate them from the human body.

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Vibrational spectroscopies to investigate concretions and ectopic calcifications for medical diagnosis

Daudon

Bazin

2016

Comptes Rendus. Chimie

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International audienceAs asserted by numerous authors, Fourier Transform (FT)-Raman and FT-Infrared spectroscopies constitute two useful tools for bio-medical diagnostics. We can distinguish two different kinds of application, namely, tissue disorders analyzed using statistical methods, and detection of ectopic calcifications through precise analysis of the shape and the position of absorption bands. In this contribution, we present some new results regarding these research themes, as well as recent experimental developments, such as the ability to perform nanometer scale near-field infrared microscopy, which have already led to major scientific breakthroughs

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A correlation study between macro- and micro-analysis of pediatric urinary calculi

Cited by 6 publications

References 21 publications

The elementome of calcium-based urinary stones and its role in urolithiasis

The elementome of calcium-based urinary stones and its role in urolithiasis

Metals in Human Gall, Bladder, and Kidney Stones Based on an Electron Microprobe Investigation

Vibrational spectroscopies to investigate concretions and ectopic calcifications for medical diagnosis

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