A correlation between the therapeutic effectiveness of certain drugs in atrial fibrillation and their action on myocardial conduction

Clinical pharmacologic observations of the effects of ajmaline in chronic atrial fibrillation

“…Ajmaline was also shown to hroaden the QRS and P waves of the dog electrocardiogram. '; Although widening is usually interpreted as a potentially dangerous action of drugs, we have previously reported 9 that all drugs which are clinically effective in chronic atrial fibrillation have this property. Finally, ajmaline can prevent or reverse experimentally induced arrhythmias of atria and ventricles of ani-Inals.…”