A Correlation Between Monocyte to Lymphocyte Ratio and Long-Term Prognosis in Patients With Coronary Artery Disease After PCI

Abstract

Monocyte to lymphocyte ratio (MLR) has been confirmed as a novel marker of poor prognosis in patients with coronary heart disease (CAD). However, the prognosis value of MLR for patients with CAD after percutaneous coronary intervention (PCI) needs further studies. In present study, we aimed to investigate the correlation between MLR and long-term prognosis in patients with CAD after PCI. A total of 3,461 patients with CAD after PCI at the First Affiliated Hospital of Zhengzhou University were included in the analysis. According to the cutoff value of MLR, all of the patients were divided into 2 groups: the low-MLR group (<0.34, n = 2338) and the high-MLR group (≥0.34, n = 1123). Kaplan–Meier curve was performed to compare the long-term outcome. Multivariate COX regression analysis was used to assess the independent predictors for all-cause mortality, cardiac mortality and MACCEs. Multivariate COX regression analysis showed that the high MLR group had significantly increased all-cause mortality (ACM) [hazard ratio (HR) = 1.366, 95% confidence interval (CI): 1.366-3.650, p = 0.001] and cardiac mortality (CM) (HR = 2.379, 95%CI: 1.611-3,511, p < 0.001) compared to the low MLR group. And high MLR was also found to be highly associated with major adverse cardiovascular and cerebrovascular events (MACCEs) (HR = 1.227, 95%CI: 1.003-1.500, p = 0.047) in patients with CAD undergoing PCI. MLR was an independent predictor of ACM, CM and MACCEs in CAD patients who underwent PCI.

Hematological Biomarkers of Troponin, Neutrophil-to-Lymphocyte Ratio, and Monocyte-toLymphocyte Ratio Serve as Effective Predictive Indicators of High-Risk Mortality in Acute

“…According to another study, MLR was independently linked to ACS and might be used to gauge the degree of coronary lesions [ 26 ]. The findings of Song et al investigation’s yielded similar results [ 27 ]. Monocytes, one of the most significant inflammatory cells, play a direct role in the emergence and progression of atherosclerosis.…”

Prognostic Impact of Multiple Lymphocyte-Based Inflammatory Indices in Acute Coronary Syndrome Patients

“…One study showed that MLR was independently associated with CAD and could be used to predict coronary lesion severity ( 30 ). The study of Song et al yielded similar results ( 31 ). As one of the most important inflammatory cells, monocytes are directly involved in the formation and development of atherosclerosis.…”

The High-Grade Oxidative Profile (OXpr), Aortic Stiffness Parameters, and Hemogram-Derived Indices (HDI) as Predictors of Long-Term Major Adverse Cardiovascular Events (MACEs) Following Percutaneous Coronary Intervention (PCI) in Patients with Non-ST-Elevation Acute Coronary Syndrome (NSTE-ACS) and Chronic Coronary Syndrome (CCS)

“…Despite the achievements of pharmacological and nonpharmacological management of cardiovascular diseases, there is a lack of effective primary, secondary, tertiary, and quaternary prevention strategies; that is why coronary heart disease (CHD) has remained the leading cause of mortality, representing 32% of all global deaths. 38,[41][42][43] In recent years, there is growing evidence regarding the role of oxidative stress, [12][13][14][15][16] arterial stiffness, [17][18][19][20][21][22][23]27,28,38,44 and nonspecific inflammation 36,39,[45][46][47][48][49][50][51][52][53][54][55][56][57][58][59][60] in the pathogenesis of the cardiovascular disease as well as prognosis of long-term cardiovascular events.…”