A Correlation Between Diet and Longevity Characterization by Means of Element Profiles in Healthy People over 80 Years from a Chinese Longevous Region

Abstract

Monitoring the element concentrations in the human body is of critical importance for health and longevity. In order to explore the formation mechanism of longevity from the perspective of the body's element loads, this study investigated the prominent feature of element profiles in healthy people over 80 years from Bama County (China), a famous longevous region (LR). The element profiles in nails of elderly people from the LR and a non-longevous region were determined by inductively coupled plasma mass spectrometry, using orthogonal projections to latent structures discriminant analysis (OPLS-DA) for pattern recognition. As a result, four characteristic elements closely related to the healthy elderly people from LR, including Cr, Fe, Mn, and Co, were identified. The concentrations of Cr, Fe, Mn, and Co were significantly increased in the LR group (p < 0.05). The values of fold change of Cr, Fe, Mn, and Co were 3.00, 2.46, 2.24, and 2.21, respectively. These characteristic elements could provide an important material guarantee for health and longevity of elderly people in the LR. The further correlation analysis revealed significant positive correlations between the Sr (r = 0.886), Mn (r = 0.873), Ni (r = 0.786), and Co (r = 0.738) concentrations in nails of elderly people and those in drinking water. Furthermore, significant positive correlations were found between the Se (r = 0.940), Mn (r = 0.833), and Fe (r = 0.733) concentrations in nails and their dietary intake. Consequently, the observations suggested that diet could provide extraordinary reference information in terms of reflecting the feature of element profiles in healthy elderly people over 80 years from the LR.

Phospholipid: diacylglycerol acyltransferase contributes to the conversion of membrane lipids into triacylglycerol in Myrmecia incisa during the nitrogen starvation stress

“…To identify the lipid that contributed to the separation of the nitrogen starvation cultivation group for 4 d from the 0 d group, 84 potential lipid biomarkers [variable importance in the projection (VIP) ranging from 3.57 to 1.00] were selected according to the VIP values as well as the corresponding 95% confidence intervals based on a jack-knife procedure and the absolute value of p(corr)3031. Of these biomarkers, the plasma-membrane lipids, PE and PC, accounted for 54.76% of the total (46 to 84) and possessed relatively high VIPs (ranging from 1.01 to 3.40), indicating that these two PLs were the main contributors to this separation.…”

Spring mineral water-borne bacteria reshape gut microbiota profiles and confer health benefits

“…It was documented that longevity of Bama centenarians is correlated with the genetic difference, mainly the polymorphism of several related genes, such as apolipoprotein C-I [21], paraoxonase 1 [22], catechism-O-methyl transferase [23], methylene tetrahydrofolate reductase [24], peroxisome proliferatoractivated receptor delta [25], cholesterol ester transfer protein [26], microsomal triglyceride transfer protein [27], and mitochondrial DNA [28]. Alternatively, dietary fibers [29] and mineral elements [30] were also attributed to longevity although the mechanisms involved are awaiting revelation.…”

Dietary Intake and Lifestyle Characteristics of Elderly Chinese Adults

“…To the Editor : Bama Yao Autonomous County, a poor but highly scenic area of Guangxi Province in southern China, has the largest number of centenarians in the world . Despite insufficient food supplies and medical coverage, many inhabitants in Bama live to be aged 100 and older, and few have health problems during their lifetime.…”