A Core Process in Receptor Function, General Anesthesia, Sleep, and Aging

Kier, Lemont B.; Slattum, Patricia W.

doi:10.1002/cbdv.201100357

Cited by 3 publications

(1 citation statement)

References 47 publications

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“…Recent studies suggest there are similarities between sleep and anesthesia-induced hypnotic effects [25,28]. However, there are still many unsolved mysteries surrounding the hypnotic mechanisms of anesthesia and sleep [22 • ].…”

Section: Sleep and Anesthesiamentioning

confidence: 99%

Mechanisms of Anesthetic Emergence: Evidence for Active Reanimation

Kushikata

Hirota

2013

Curr Anesthesiol Rep

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Historically, emergence from anesthesia was believed to progress only through the passive elimination of pharmacologic agents from the brain. However, recent studies indicate that anesthetic emergence may not simply be a process mirroring the induction of anesthesia. Several substances reduce the duration of anesthesia but not its induction time. Their action is not the result of a passive process, because they actively affect the kinetics of neurotransmitters or the endogenous sleep circuit to shorten anesthesia. The latest notable substance among this group of agents is methylphenidate, an inhibitor of dopamine and norepinephrine transporters. Studies on emergence from anesthesia aim not only to stimulate scientific interest but also to improve the clinical course following general anesthesia, when patients sometimes experience life-threatening complications such as myocardial infarction, bronchial asthma, and cerebral hemorrhage. This review discusses recent advances in this field, focusing mainly on the role of neurotransmitters and neuromodulators in anesthetic emergence.

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Section: Sleep and Anesthesiamentioning

confidence: 99%

Mechanisms of Anesthetic Emergence: Evidence for Active Reanimation

Kushikata

Hirota

2013

Curr Anesthesiol Rep

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Anesthetic activity and the electrostatic potential (revisited)

Shields¹,

Seybold

Murray

2017

J Mol Model

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A survey of the fascinating history of anesthetics and the many critical findings that have improved our understanding of anesthetic activity is followed by an expanded analysis of the electrostatic potentials of 27 molecules and two noble gases with anesthetic activities ranging from high to totally inactive. We again find that an intermediate value for the internal charge separation (polarity) Π appears to be an important factor in anesthetic activity. Other electrostatic potential features that favor high anesthetic activity include the presence of at least one strongly positive site on the molecule and regions of weakly to moderately negative electrostatic potential. For 14 molecules with consistent anesthetic activity data, we find a reasonable multivariable correlation that reflects the above features and also includes a measure of molecular size, reflecting the polarizability. The commonalities found in the electrostatic potential data for the active anesthetics suggest that anesthetics interact via their positive and/or negative sites in noncovalent reversible interactions with target sites, perhaps in brain proteins.

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A Physical Theory of Sleep Involving Nitrogen Nanobubbles and Proton Hopping

Basak

Kier

2018

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A Core Process in Receptor Function, General Anesthesia, Sleep, and Aging

Cited by 3 publications

References 47 publications

Mechanisms of Anesthetic Emergence: Evidence for Active Reanimation

Mechanisms of Anesthetic Emergence: Evidence for Active Reanimation

Anesthetic activity and the electrostatic potential (revisited)

A Physical Theory of Sleep Involving Nitrogen Nanobubbles and Proton Hopping

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