A Copper-Responsive Two-Component System Governs Lipoprotein Remodeling in Listeria monocytogenes

Komazin, Gloria; Rizk, Amena A; Armbruster, Krista M.; Bonnell, Victoria; Llinás, Manuel; Meredith, Timothy C.

doi:10.1128/jb.00390-22

J Bacteriol

2023

DOI: 10.1128/jb.00390-22

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A Copper-Responsive Two-Component System Governs Lipoprotein Remodeling in Listeria monocytogenes

Gloria Komazin

Amena A Rizk

Krista M. Armbruster

et al.

Abstract: Copper is a frontline antimicrobial used to limit bacterial growth in multiple settings. Here, we demonstrate how the response regulator CopR from a plasmid-borne two-component system in the opportunistic pathogen L. monocytogenes directly induces lipoprotein remodeling in tandem with copper resistance genes due to extracellular copper stress.

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Revisiting old friends: updates on the role of two-component signaling systems in Listeria monocytogenes survival and pathogenesis

Alejandro-Navarreto,

Freitag

2024

Infect Immun

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Listeria monocytogenes is well recognized for both its broad resistance to stress conditions and its ability to transition from a soil bacterium to an intracellular pathogen of mammalian hosts. The bacterium’s impressive ability to adapt to changing environments and conditions requires the rapid sensing of environmental cues and the coordinated response of gene products that enable bacterial growth and survival. Two-component signaling systems (TCSs) have been long recognized for their ability to detect environmental stimuli and transmit those signals into transcriptional responses; however, often the precise nature of the stimulus triggering TCS responses can be challenging to define. L. monocytogenes has up to 16 TCSs that have been recognized based on homology and included in this list are several whose functions remain poorly described. This review highlights the current understanding of the breadth and scope of L. monocytogenes TCS as relates to stress resistance and pathogenesis. Precise signals still often remain elusive, but the gene networks associated with TCSs are providing clues into possible functions.

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Revisiting old friends: updates on the role of two-component signaling systems in Listeria monocytogenes survival and pathogenesis

Alejandro-Navarreto,

Freitag

2024

Infect Immun

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The Extracellular Electron Transport Pathway Reduces Copper for Sensing by the CopRS Two-Component System under Anaerobic Conditions in Listeria monocytogenes

et al. 2023

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Two-component extracellular copper sensing from the periplasm of Gram-negative bacteria has been well studied, but copper detection at the cell surface of the Gram-positive L. monocytogenes is less understood. Collectively, our results show that EET is most active under anaerobic conditions and reduces Cu 2+ and Ag 1+ to, respectively, generate or remove the monovalent ligands that directly bind to CopS and lead to the induction of lipoprotein remodeling genes.

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A Copper-Responsive Two-Component System Governs Lipoprotein Remodeling in Listeria monocytogenes

Cited by 2 publications

References 84 publications

Revisiting old friends: updates on the role of two-component signaling systems in Listeria monocytogenes survival and pathogenesis

Revisiting old friends: updates on the role of two-component signaling systems in Listeria monocytogenes survival and pathogenesis

The Extracellular Electron Transport Pathway Reduces Copper for Sensing by the CopRS Two-Component System under Anaerobic Conditions in Listeria monocytogenes

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