A copper–cyclen coordination complex associated with a polyoxometalate anion: Synthesis, crystal structure and electrochemistry of [Cu(cyclen)(MeCN)][W6O19]

Lights and shadows in the challenge of binding acyclovir, a synthetic purine-like nucleoside with antiviral activity, at an apical–distal coordination site in copper(II)-polyamine chelates

“…Thereby it gives Cu(II) macrochelates with a frequent 4 + 1 coordination, with only one apical site. At this apical position we can found aqua [52,53], acetonitrile [54] and various anions, including the purinate(1−) anionic ligand studied by K. Aoki et al [31]. On this basis, the possibilities of binding acv at the apical coordination site were expected to be improved.…”

Advances in the synthesis and applications of macrocyclic polyamines

“…Owing to its good solubility in DMF, NaH can react without the need for a phase transfer catalyst, resulting in an average yield of approximately 30%. Inorganic bases such as potassium carbonate and caesium carbonate also significantly influence the cyclization yield [16,[80][81][82]. In general, the weaker the alkalinity, the longer the reaction time required and the reaction generally needs to be carried out in a dilute solution.…”

Crystal structure of (perchlorato-κO)(1,4,7,10-tetraazacyclododecane-κ4N)copper(II) perchlorate

“…A database survey resulted in several similar Cu-cyclen complexes with five-coordinate copper(II). Four structures chosen for further analysis contained a copper(II) ion coordinated by either five nitrogen atoms or four nitrogen atoms and one oxygen atom (Rohde & Merzweiler, 2010;Sarma et al, 2010;Pé ré z-Toro et al, 2015;Guo et al, 2008). Where applicable, the complexes have similar Cu-O bond lengths to that of the title complex, with only slight deviations.…”