A convergent total synthesis of resorcylic acid lactones zeaenol and cochliomycin A

Nasam, Rajesh; Srihari, P.

doi:10.1016/j.tetlet.2022.153777

Tetrahedron Letters

2022

DOI: 10.1016/j.tetlet.2022.153777

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A convergent total synthesis of resorcylic acid lactones zeaenol and cochliomycin A

Rajesh Nasam

P. Srihari

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2023

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A Convergent Approach for the Synthesis of C14–C26 Fragment of Anticancer Drug Eribulin Mesylate

Pabbaraja,

Nasam

2023

Synthesis

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The stereoselective synthesis of C14-C26 fragment of eribulin is reported in a convergent way by coupling of fragment C14-C19 with fragment C20-C26 that are accessible from commercially available raw materials crotonic acid and 1,4-butanediol. The key steps involved in this practical approach are Hosomi-Sakurai asymmetric alkylation, Maruoka allylation, Noyori reduction, silver catalyzed one pot rearrangement and intramolecular cyclization

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A Convergent Approach for the Synthesis of C14–C26 Fragment of Anticancer Drug Eribulin Mesylate

Pabbaraja,

Nasam

2023

Synthesis

Self Cite

View full text Add to dashboard Cite

show abstract

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A convergent total synthesis of resorcylic acid lactones zeaenol and cochliomycin A

Cited by 1 publication

References 50 publications

A Convergent Approach for the Synthesis of C14–C26 Fragment of Anticancer Drug Eribulin Mesylate

A Convergent Approach for the Synthesis of C14–C26 Fragment of Anticancer Drug Eribulin Mesylate

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