A convergent approach to sulfonimide-based dendrimers and dendrons

Bondareva, Julia; Kolotylo, Mykola V.; Rozhkov, Vladimir V.; Burilov, Vladimir; Lukin, Oleg

doi:10.1016/j.tetlet.2020.152011

Cited by 10 publications

(23 citation statements)

References 44 publications

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“…Synthetic methods are generally divided into two categories: step-growth polymerization [205] and chain polymerization [206]. The essential difference between these two processes is that in chain polymerization, monomers are added to the chain one at a time only, whereas in step-growth polymerization, chains of monomers are combined with one another directly.…”

Section: Main Synthesizing Methodsmentioning

confidence: 99%

Synergic Antitumor Effect of Photodynamic Therapy and Chemotherapy Mediated by Nano Drug Delivery Systems

et al. 2022

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This review provides a summary of recent progress in the development of different nano-platforms for the efficient synergistic effect between photodynamic therapy and chemotherapy. In particular, this review focuses on various methods in which photosensitizers and chemotherapeutic agents are co-delivered to the targeted tumor site. In many cases, the photosensitizers act as drug carriers, but this review, also covers different types of appropriate nanocarriers that aid in the delivery of photosensitizers to the tumor site. These nanocarriers include transition metal, silica and graphene-based materials, liposomes, dendrimers, polymers, metal–organic frameworks, nano emulsions, and biologically derived nanocarriers. Many studies have demonstrated various benefits from using these nanocarriers including enhanced water solubility, stability, longer circulation times, and higher accumulation of therapeutic agents/photosensitizers at tumor sites. This review also describes novel approaches from different research groups that utilize various targeting strategies to increase treatment efficacy through simultaneous photodynamic therapy and chemotherapy.

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Section: Main Synthesizing Methodsmentioning

confidence: 99%

Synergic Antitumor Effect of Photodynamic Therapy and Chemotherapy Mediated by Nano Drug Delivery Systems

et al. 2022

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“…They described the synthesis of first-to-third generations of sulfonamide-based dendrons with reactive chlorosulfo-groups at their focal points. They concluded that the convergent approach is limited up to the third generation while the divergent approach can achieve higher generations [ 42 ].…”

Section: Synthesis Routesmentioning

confidence: 99%

Developments in Treatment Methodologies Using Dendrimers for Infectious Diseases

Filipczak

Yalamarty

et al. 2021

Molecules

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Dendrimers comprise a specific group of macromolecules, which combine structural properties of both single molecules and long expanded polymers. The three-dimensional form of dendrimers and the extensive possibilities for use of additional substrates for their construction creates a multivalent potential and a wide possibility for medical, diagnostic and environmental purposes. Depending on their composition and structure, dendrimers have been of interest in many fields of science, ranging from chemistry, biotechnology to biochemical applications. These compounds have found wide application from the production of catalysts for their use as antibacterial, antifungal and antiviral agents. Of particular interest are peptide dendrimers as a medium for transport of therapeutic substances: synthetic vaccines against parasites, bacteria and viruses, contrast agents used in MRI, antibodies and genetic material. This review focuses on the description of the current classes of dendrimers, the methodology for their synthesis and briefly drawbacks of their properties and their use as potential therapies against infectious diseases.

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“…First reported by Hawker and Fréchet for the synthesis of poly(phenyl benzyl ether) dendrimers, ref [54] the convergent method ensures the precise placement of functional groups throughout the dendritic structure that enables the synthesis of functional macromolecules. Though several dendrimers are reported recently employing the convergent method of synthesis, refs [21,24,[54][55][56][57][58][59][60][61][62][63][64][65][66][67][68][69][70][71][72] there are very few reports on polyurethane dendrimers using this method [40,[73][74][75].…”

Section: Introductionmentioning

confidence: 99%

“…employing the convergent method of synthesis, refs [21,24,[54][55][56][57][58][59][60][61][62][63][64][65][66][67][68][69][70][71][72] the ports on polyurethane dendrimers using this method [40,[73][74][75].…”

Section: Introductionmentioning

confidence: 99%

Thiol-Ene Click-Inspired Late-Stage Modification of Long-Chain Polyurethane Dendrimers

Poudel

Taylor

2021

Reactions

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The construction of well-defined polyurethane dendrimers is challenging due to the high reactivity of externally added or in situ formed isocyanates leading to the formation of side products. With a primary focus of dendrimer research being the interaction of the periphery and the core, we report the synthesis of a common polyurethane dendron, which allows for the late-stage variation of both the periphery and the core. The periphery can be varied simply by installing a clickable unit in the dendron and then attaching to the core and vice-versa. Thus, a common dendron allows for varying periphery and core in the final two steps. To accomplish this, a protecting group-free, one-pot multicomponent Curtius reaction was utilized to afford a robust and versatile AB2 type polyurethane dendron employing commercially available simple molecules: 5-hydroxyisophthalic acid, 11-bromoundecanol, and 4-penten-1-ol. Subsequent late-stage modifications of either dendrons or dendrimers via a thiol-ene click reaction gave surface-functionalized alternating aromatic-aliphatic polyurethane homodendrimers to generation-three (G3). The dendrons and the dendrimers were characterized by NMR, mass spectrometry, and FT-IR analysis. A bifunctional AB2 type dendritic monomer demonstrated this approach’s versatility that can either undergo a thiol-ene click or attachment to the core. This approach enables the incorporation of functionalities at the periphery and the core that may not withstand the dendrimer growth for the synthesis of polyurethane dendrimers and other dendritic macromolecules.

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A convergent approach to sulfonimide-based dendrimers and dendrons

Cited by 10 publications

References 44 publications

Synergic Antitumor Effect of Photodynamic Therapy and Chemotherapy Mediated by Nano Drug Delivery Systems

Synergic Antitumor Effect of Photodynamic Therapy and Chemotherapy Mediated by Nano Drug Delivery Systems

Developments in Treatment Methodologies Using Dendrimers for Infectious Diseases

Thiol-Ene Click-Inspired Late-Stage Modification of Long-Chain Polyurethane Dendrimers

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