A Convenient Synthesis of N2-Alkylated Guanines

Protocols for Efficient Chemical Synthesis of N2‐Modified Guanosine Phosphate Derivatives: Versatile Probes for mRNA Labeling

“…However, the synthesis of the starting material, 2‐halopurine is tedious, time‐consuming, and expensive, involving more than three chemical steps. Another method involves a three‐step synthesis of N 2 ‐alkylguanine starting from N 2 ‐Boc‐protected 2‐amino‐6‐chloropurine (Fletcher et al., 2010; Zhu et al., 2019). The overall method involves protection at the N 9 position of the guanine, alkylation at the N 2 position, and then deprotection to afford the corresponding N 2 ‐alkylguanine.…”