A Convenient Synthesis of 1,2,5-Trisubstituted 4,5-Dihydroimidazoles and 1,3-Diazaspiro [4.4(5)]alk-2-enes from<i>N</i>-Alkylideneanilines

Naim, S. S.; Sharma, Satyavan

doi:10.1055/s-1992-26194

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Ethyl 3-cyano-3-phenylamino-3-(4-methoxyphenyl)propanoate (4f)1

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2020

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Cited by 10 publications

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“…A solution of KHMDS (94.4 mg, 0.473 mmol) in THF (5 mL) was added within 3 min to a stirred solution of α-(phenylamino)-4-methoxyphenylacetonitrile (3f; [16,19] 102 mg, 0.430 mmol) in THF (10 mL) at -78°C. Ethyl bromoacetate (77.9 mg, 0.473 mmol, 53.5 µL) in THF (3 mL) was added immediately after addition of the KHMDS solution, and the mixture was allowed to stir for 1 h at -78°C.…”

Section: Ethyl 3-cyano-3-phenylamino-3-(4-methoxyphenyl)propanoate (4f)mentioning

confidence: 99%

Microwave‐Assisted Synthesis of Polysubstituted 4‐Quinolones from Deprotonated α‐Aminonitriles

Romek

Opatz

2010

Eur J Org Chem

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Section: Ethyl 3-cyano-3-phenylamino-3-(4-methoxyphenyl)propanoate (4f)mentioning

confidence: 99%

Microwave‐Assisted Synthesis of Polysubstituted 4‐Quinolones from Deprotonated α‐Aminonitriles

Romek

Opatz

2010

Eur J Org Chem

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Catalytic Synthesis of 1,2,4,5‐Tetrasubstituted 1H‐Imidazole Derivatives: State of the Art

et al. 2019

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1,2,4,5-Tetrasubstituted-1H-imidazoles are a large family of heteroarene derivatives that are known to include natural products isolated from marine sponges and synthetic compounds possessing a broad range of biological and pharmacological properties. Consequently, a great deal of attention has been given to the synthesis of these heteroarenes and reviews covering some synthetic aspects of this topic have been published in recent years. However, none of these reviews provides a comprehensive overview of the several catalytic methods developed in the literature for the preparation of this important class of heteroarenes. This article review with 469 references, 63% of them being related to the period 2010-2017, aims to provide an updated critical picture of the catalytic processes reported in the literature up to the end of 2017 for the synthesis of 1,2,4,5-tetrasubstituted-1H-imidazoles illustrating these protocols and their characteristic features such as scope, efficiency, versatility, and limitations. The review also summarizes the mechanisms of the catalytic processes proposed for many of the reported processes.

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Synthesis of Spiroguanidine Derivatives by Dearomative Oxidative Cyclization using Hypervalent Iodine Reagent

et al. 2020

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A Convenient Synthesis of 1,2,5-Trisubstituted 4,5-Dihydroimidazoles and 1,3-Diazaspiro [4.4(5)]alk-2-enes fromN-Alkylideneanilines

Cited by 10 publications

References 0 publications

Microwave‐Assisted Synthesis of Polysubstituted 4‐Quinolones from Deprotonated α‐Aminonitriles

Microwave‐Assisted Synthesis of Polysubstituted 4‐Quinolones from Deprotonated α‐Aminonitriles

Catalytic Synthesis of 1,2,4,5‐Tetrasubstituted 1H‐Imidazole Derivatives: State of the Art

Synthesis of Spiroguanidine Derivatives by Dearomative Oxidative Cyclization using Hypervalent Iodine Reagent

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