A convenient preparation of the amminetrichloroplatinate(II) anion

Bifunctional Bioorganometallic Iridium(III)–Platinum(II) Complexes Incorporating Both Intercalative and Covalent DNA Binding Capabilities

“…[17] [(η 5 -Cp*)Ir(dppz)(H-Gly-Met-OH- [16] and [(η 5 -Cp*)Ir(dppz)(H-Gly-Gly-Met-OH-κS)](CF 3 SO 3 ) 2 were prepared from 1 and the relevant peptide in a manner previously described for the latter complex. [14] (Et 4 N) [ [36] [(η 5 -Cp*)Ir(dppz)(H-Gly-Gly-Phe-Met-OH-κS)](CF 3 SO 3 ) 2 (3): The ligand dppz (56.5 mg, 0.2 mmol) was added to 1 (159.8 mg, 0.2 mmol) in CH 3 OH/CH 2 Cl 2 (10 mL) and the resulting solution stirred at reflux for 2 h. After addition of H-Gly-Gly-Phe-Met-OH (82.1 mg, 0.2 mmol) in CF 3 COOH (1.5 mL) and stirring at 50°C for 18 h, the volume was reduced to 3 mL. The product was precipitated by addition of diethyl ether, washed and dried in vacuo.…”

Effects of Spectator Ligands on the Specific Recognition of Intrastrand Platinum-DNA Cross-links by High Mobility Group Box and TATA-binding Proteins

“…In addition to cisplatin, five other platinum complexes were examined. Two complexes with bidentate chelating ligands were chosen, [Pt-(dach)Cl 2 ], which forms the same lesions as those of oxaliplatin (23), and [Pt(en)I 2 ], a complex frequently used to model cisplatin activity (12 (27,28).…”

2.4-Å Crystal Structure of the Asymmetric Platinum Complex {Pt(ammine)(cyclohexylamine)}2+ Bound to a Dodecamer DNA Duplex

“…This work significantly extends the structural information available on platinum-DNA adducts and offers insights into the differences and common features between a variety of platinated DNA structures. (19,20). Crystallization reagents were obtained from Aldrich, Fluka, and Sigma.…”