A controlled trial of thiopropazate and dehydrochloride (Dartalan), chlorpromazine and occupational therapy in chronic schizophrenics

Hamilton, Max; Smith, Arthur L.; Lapidus, H E; Cadogan, E P

doi:10.1097/00006199-196101040-00037

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“…Before the trial began and during weeks 12, 24, 40 and at the time of withdrawal, the patient'smental statewasassessed independently by two psychiatrists, using the Hamilton-Lorr Scale (Hamilton et a!, 1960); depression and anxiety were also assessedusing the relevant sections of the Krawiecka Scale (Krawiecka eta!, 1977). The patient's ward behaviour was assessed by a senior nurse,using the Wing Ward Behaviour Scale (Wing, 1961), and the ability to work in the industrial therapy unit by senior nursing staff and instructors, using a standardized work report (Grif fiths,1973).Parkinsonianside-effects (tremor,rigidity, dystonia, akathisia) were assessed jointly by two psychiatrists using a five-point scale(0 = absent, 1 = doubtful, 2 = mild, 3 = moderate, 4 = severe).…”

Section: Assessmentmentioning

confidence: 99%

Once Weekly Pimozide versus Fluphenazine Decanoate as Maintenance Therapy in Chronic Schizophrenia

et al. 1982

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In a double blind trial, 28 male chronic schizophrenic in-patients received either pimozide, given once weekly, or fluphenazine decanoate, given mostly once fortnightly. There was no difference in relapse rates over nine months. However, three-quarters of the patients on pimozide who completed the trial developed at least mild tardive dyskinesia. All patients on pimozide lost weight, the average loss being 5.4 kg (12 lbs). Plasma pimozide levels suggested satisfactory drug compliance. Plasma prolactin levels confirmed that in the pimozide group there was fluctuating dopamine receptor antagonism, while in the fluphenazine group average plasma prolactin levels throughout most of the interval between injections were at the upper limit of normal.

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Section: Assessmentmentioning

confidence: 99%