A Controlled Trial of the Effect of Linolenic Acid on Incidence of Coronary Heart Disease

Natvig, H; Borchgrevink, F.; Dedichen, J; Owren, P. A.; Schiotz, E H; Westlund, Knut

doi:10.1080/00365516809168196

Cited by 21 publications

(22 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The effect of a-linolenic acid supplementation in CHD prevention has been examined in five trials (Natvig et al 1968;Singh et al 1997Singh et al , 2002de Lorgeril et al 1999;Bemelmans et al 2002). The Indian Experiment of Infarct Survival (Singh et al 1997), discussed earlier, has reported a decrease in total cardiac events in the group assigned to mustard-seed oil.…”

Section: Fatty Acid Intervention Studies and Chdmentioning

confidence: 99%

“…These three positive studies of a-linolenic acid are balanced by two negative studies (Natvig et al 1968;Bemelmans et al 2002). In the Norwegian Vegetable Oil Experiment (Natvig et al 1968) 13 000 men aged 50-59 years with no history of MI were randomly assigned to consume either 5 .…”

Section: Fatty Acid Intervention Studies and Chdmentioning

confidence: 99%

“…In the Norwegian Vegetable Oil Experiment (Natvig et al 1968) 13 000 men aged 50-59 years with no history of MI were randomly assigned to consume either 5 . 5 g a-linolenic acid (from 10 ml linseed oil)/d or 10 ml sunflower oil/d for 1 year.…”

Section: Fatty Acid Intervention Studies and Chdmentioning

confidence: 99%

See 2 more Smart Citations

Fatty acids and CHD

Woodside¹,

Kromhout

2005

Proc. Nutr. Soc.

View full text Add to dashboard Cite

During the last century much evidence has accumulated to suggest that from a public health perspective the type of fat is more important than the amount of fat. Saturated and trans-fatty acids increase and both n-6 and n-3 PUFA decrease the risk of CHD. Most of the knowledge about the effects of dietary fatty acids on CHD risk is based on observational studies and controlled dietary experiments with intermediate end points (e.g. blood lipoprotein fractions). Information from high-quality randomised controlled trials on fatty acids and CHD is lacking. The Netherlands Institute for Public Health has calculated the potential health gain that can be achieved if the fatty acid composition of the current Dutch diet is replaced by the recommended fatty acid composition. The recommendations of The Netherlands Health Council are: saturated fatty acids < 10 % energy intake; trans-fatty acids < 1 % energy intake; fish consumption (an indicator of n-3 PUFA) once or twice weekly. Implementation of this recommendation could reduce the incidence of CHD in The Netherlands by about 25 000/year and the number of CHD-related deaths by about 6000/year and increase life expectancy from age 40 years onwards by 0 . 5 year. These projections indicate the public health potential of interventions that modify the fatty acid composition of the diet.

show abstract

Section: Fatty Acid Intervention Studies and Chdmentioning

confidence: 99%

Section: Fatty Acid Intervention Studies and Chdmentioning

confidence: 99%

See 1 more Smart Citation

Fatty acids and CHD

Woodside¹,

Kromhout

2005

Proc. Nutr. Soc.

View full text Add to dashboard Cite

show abstract

“…The treatment did not have any beneficial health effect compared with a placebo (2,3). However, known risk factors such as high blood pressure (7), high body mass index (BMI) (8) and cigarette smoking (9) were associated with a higher risk of ischaemic heart disease (2, 3).…”

mentioning

confidence: 99%

“…The purpose of this study was to determine whether and to what extent the results of these routine check-ups by company medical officers can predict lost years of life and mortality due to various causes. In addition to blood pressure, body mass index and smoking habits, we examined the association with sedimentation rate (3,10).…”

mentioning

confidence: 99%