A Controlled Trial of Polyglytone 6211 versus Poliglecaprone 25 for Use in Intradermal Suturing in Dogs

Abstract

The objective of this work was the comparative evaluation of the healing process after employing 4/0 poliglecaprone 25 and 4/0 polyglytone 6211 in a continuous intradermal suture pattern. Ten Beagle dogs were used, in which skin incisions were created surgically and subsequently were sutured by means of continuous intradermal pattern using polyglytone 6211 or poliglecaprone 25 suture. Cosmetic, clinical, and histologic scores were evaluated. The cosmetic appearance of the wounds was blindly evaluated on days 7, 14, 28, 180, 360, 730, and 1095. On the same days, tissue biopsy was performed for histological evaluation. Clinical evaluation was performed initially daily, then weekly, monthly, and finally yearly, till day 1095. The clinical appearance of the intradermal pattern with both sutures was initially very good, deteriorated in the second post-operative month and thereafter improved. The cosmetic, clinical, and histological differences between the two suture materials were minimal and statistically insignificant. Polyglytone 6211 is sufficient for use in intradermal suturing in dogs. However, its earlier absorption compared to poliglecaprone 25 did not have any beneficial effect on cutaneous wound healing and scar appearance in the experimental animals.

Evaluation of Incisional Wound Healing in Dogs after Closure with Staples or Tissue Glue and Comparison to Intradermal Suture Pattern

“…It is generally assumed that the intradermal suture pattern has superior cosmetic results, mainly because the epidermis is not penetrated [25], and, therefore, inflammation remains minimal, whilst a fine approximation of wound edges can also be achieved, resulting in minimal scarring [26]. However, although it is considered a better option for skin closure [5], continuous intradermal suture pattern is both technically demanding and time-consuming [1][2][3][4][5]. Alternative closure techniques or materials, such as tissue adhesives and skin staples are credited for faster closure and easier application; however, they have not been tested thoroughly in dogs yet.…”

“…Histological evaluation of the healing process was performed on postoperative days 7, 14, 28, 180 and 365 [4,5,[17][18][19][20]. Eight-millimeter punch biopsy samples [21] were taken from the incisions (the first, 1 cm away from the lower commissure of the incision; the others, 1.5 cm apart between them, proximally) and were immediately bisected, under magnification, perpendicularly to the incision.…”

“…Gouletsou et al [4,5] observed that skin thickening at the wound area with the intradermal technique, performed with a 4-0 suture, was large on the 1st po.d. and then it decreased gradually until the 20th po.d.…”

“…Most surgical wounds are typically treated by first intention healing with the use of sutures. Continuous intradermal skin closure has become increasingly popular in surgical procedures in small animals [1][2][3][4][5][6] since it has many advantages, including decreased scar formation, no need for suture removal, and reduction of tissue inflammation and self-induced trauma [6]. However, even if it is considered to be a better option for skin closure [5], continuous intradermal closure is technically demanding and time-consuming [1][2][3][4][5].…”

“…Continuous intradermal skin closure has become increasingly popular in surgical procedures in small animals [1][2][3][4][5][6] since it has many advantages, including decreased scar formation, no need for suture removal, and reduction of tissue inflammation and self-induced trauma [6]. However, even if it is considered to be a better option for skin closure [5], continuous intradermal closure is technically demanding and time-consuming [1][2][3][4][5]. Alternative closure techniques or materials, such as tissue adhesives (glue) and skin staples, have been used mainly in humans and are preferred in many cases, since are credited for faster closure and easy application.…”