A Controlled Trial of Colchicine in Preventing Attacks of Familial Mediterranean Fever

Zemer, Deborah; Revach, Moshe; Pras, Mordechai; Modan, Baruch; Schor, Stanley S.; Sohar, Ezra; Gafni, Joseph

doi:10.1056/nejm197410312911803

Cited by 353 publications

(116 citation statements)

References 8 publications

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“…In type II, the first presentation of FMF is either proteinuria or nephrotic syndrome due to renal amyloidosis (11). Regular colchicine treatment may prevent amyloidosis and decrease kidney damage in patients with proteinuria (12). In addition to amyloidosis, the patients with FMF may have other glomerular disease such as vasculitis, crescentic rapidly progressive glomerulonephritis, mesangial IgA nephropathy, IgM nephropathy and diffuse proliferative glomerulonephritis.…”

Section: Discussionmentioning

confidence: 99%

Diffusion-weighted MR imaging of kidneys in patients with familial mediterranean fever: initial experience

Karadeli

Ulu²,

Yılmaz³

et al. 2009

Diagn Interv Radiol

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Section: Discussionmentioning

confidence: 99%

Diffusion-weighted MR imaging of kidneys in patients with familial mediterranean fever: initial experience

Karadeli

Ulu²,

Yılmaz³

et al. 2009

Diagn Interv Radiol

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“…So for the modification of the effect of the triggers on the risk of FMF attacks, physiotherapy could be an alternative approach. Treatment with 1-2 mg of colchicine a day has been shown to prevent or alleviate the attacks in the majority of patients (20,21). In the presence of colchicine, low and moderate-intensity exercise, relaxation exercises, breathing exercises for the pulmonary manifestations of FMF and relaxation could be used.…”

Section: Discussionmentioning

confidence: 99%

A possible relationship between respiratory muscle weakness and familial mediterranean fever: a case report

Çirak

Yılmaz

Demir

et al. 2014

Turk J Physiother Rehabil

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To Familial Mediterranean Fever (FMF) is an autoinflammatory disorder with genetic origin. Pleuritis is most common in FMF. Long-term sequelae of respiratory system haven't been described in FMF. We documented pulmonary manifestations in patient with FMF. A 61-year-old woman presented with dyspnea, unilateral chest pain, generalized myalgia and FMF. Physical examination was unremarkable. Radiological data showed left-sided pleuritis, minimal pleural effusion. Pleural effusion resolved spontaneously in one week later but patient had still dyspnea. Pulmonary function tests (PFT) was normal. Further examination detected respiratory muscle weakness and decreased functional capacity. Patient then underwent inspiratory muscle training (IMT) for six weeks. After training, inspiratory muscle strength and functional capacity increased. Perception of dyspnea and fatique decreased. In long-term follow-up, frequency of attacks decreased. To our knowledge, there is no study on respiratory muscle weakness and IMT in FMF. Although this report doesn't provide direct evidence, it may provide recommendation for investigation of respiratory muscle weakness and treatment with IMT in FMF with respiratory impairments. Randomized controlled trials are needed.Key words: Chronic disease, rehabilitation, physiotherapy, familial mediterranean fever VAKA RAPORU SOLUNUM KAS ZAYIFLIĞI VE AİLEVİ AKDENİZ ATEŞİ ARASINDAKİ OLASI İLİŞKİ: VAKA RAPORU ÖZETAilevi Akdeniz Ateşi ( AAA ) genetik kökenli oto-inflamatuar bir hastalıktır. Plörit AAA'da çok sık görülür. Solunum sistemi üzerinde AAA'nin uzun dönem etkileri tanımlanmamıştır. AAA'li bir hastada akciğerdeki etkilenimleri gösterdik. 61 yaşında AAA'li kadın hasta, nefes darlığı, tek taraflı göğüs ağrısı ve yaygın kas ağrısı şikayetiyle başvurdu. Fizik muayenede belirgin bir bulgu yoktu. Radyolojik bulgular sol taraflı plöriti ve minimal plevral efüzyonu gösteriyordu. Plevral efüzyon, bir hafta içinde kendiliğinden çözüldü ama hastanın nefes darlığı şikayeti devam ediyordu. Solunum fonksiyon testi değerleri ( SFT ) normaldi. Ayrıntılı değerlendirmede solunum kas zayıflığı ve fonksiyonel kapasitede azalma tespit edildi. Daha sonra hastaya altı hafta boyunca inspiratuar kas eğitimi ( IMT ) uygulandı. Eğitimden sonra, hastanın inspiratuar kas kuvveti ve fonksiyonel kapasitesi arttı. Nefes darlığı ve yorgunluk algısı azaldı. Uzun süreli takipte, atak sıklığı azaldı. Bizim bilgimize göre literatürde, AAA'de solunum kas zayıflığı ve IMT ile ilgili çalışma yok. Bu vaka raporu, doğrudan kanıt olmamasına rağmen, solunum sıkıntısı olan AAA'li hastalarda, solunum kas zayıflığının araştırılması ve tedavide IMT'nin kullanılması yönünde öneriler sağlayabilir. Randomize kontrollü çalışmalara ihtiyaç vardır.

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“…In addition to its use in gout, it has also been recommended in preventing attacks of familial Mediterranean fever, and in the treatment of primary biliary cirrhosis, amyloidosis, and condyloma acuminata [8,10]. At micromolar concentrations, it suppresses monosodium urate crystal-induced NACHT-LRR-PYD-containing protein-3 (NALP3) inflammasome-driven caspase-1 activation, IL-1beta processing and release, and L-selectin expression on neutrophils; at nanomolar concentrations, colchicine blocks the release of a crystal-derived chemotactic factor from neutrophil lysosomes, blocks neutrophil adhesion to endothelium by modulating the distribution of adhesion molecules on the endothelial cells, and inhibits monosodium urate crystal-induced production of superoxide anions from neutrophils [7].…”

Section: Discussionmentioning

confidence: 99%

Patient risk factors and adverse drug interactions in the treatment of acute gouty arthritis in the elderly: a case report

et al. 2009

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IntroductionNon-steroidal anti-inflammatory drugs and corticosteroids are both used in the treatment acute gouty arthritis and may adversely interact with colchicine. Gastrointestinal toxicity of colchicine is dose-dependent and can be aggravated by drug-drug and drug-patient interactions.Case presentationColonic perforation associated with second-line administration of colchicine for acute gouty arthrtitis was identified in an elderly man with several comorbidities who was also treated with non-steroidal anti-inflammatory drugs and corticostroids. Underlying diverticular disease was discovered at the time of surgical therapy.ConclusionsInitial treatment of acute gouty arthritis with non-steroidal anti-inflammatory drugs or corticosteroids may increase colchicine toxicity by subsequent pharmacokinetic and pharmacodynamic interaction in the gut wall. The literature is reviewed suggesting that diverticular disease should be included in the list of adverse event risk factors when colchicine is being considered.

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A Controlled Trial of Colchicine in Preventing Attacks of Familial Mediterranean Fever

Cited by 353 publications

References 8 publications

Diffusion-weighted MR imaging of kidneys in patients with familial mediterranean fever: initial experience

Diffusion-weighted MR imaging of kidneys in patients with familial mediterranean fever: initial experience

A possible relationship between respiratory muscle weakness and familial mediterranean fever: a case report

Patient risk factors and adverse drug interactions in the treatment of acute gouty arthritis in the elderly: a case report

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