A Controlled Trial of Artificial Respiration in the Respiratory-Distress Syndrome of the Newborn

Reid, D.H.S.; Tunstall, M.E.; Mitchell, Robert J.

doi:10.1016/s0140-6736(67)92112-5

Cited by 32 publications

(12 citation statements)

References 9 publications

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“…The intensive care with IPPV treatment of VLBW infants is currently under debate (8,11,14,16). The survival rate for AR patients even with a birth weight below 1.0 kg was high in our material.…”

Section: Discussionmentioning

confidence: 99%

“…Since the late nineteen-sixties intermittent positive pressure ventilation (IPPV) for respiratory insufficiency in newborn infants has become a routine procedure in most neonatal intensive care units (4,6, 11,12). The decision to start IPPV involves weighing the immediate risk of death or damage caused by expectancy against the short-term and long-term risks involved in mechanical ventilation.…”

mentioning

confidence: 99%

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EVALUATION OF MECHANICAL VENTILATION IN NEWBORN INFANTS: I. Techniques and survival rates

et al. 1980

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The short-term outcome with survival rate, causes of death and neonatal complications in a 6-year material comprising 253 infants treated with intermittent positive pressure ventilation (IPPV) in the neonatal period has been analyzed in relation to different primary disorders necessitating IPPV treatment. The total survival rate was 53%. For the different diagnoses the survival rates were: hyaline membrane disease (HMD) 41%, apnoea repetens of immaturity 85%, severe birth asphyxia 46% and septicemia 59%. The total rate of pneumothorax during IPPV was 15% but occurred more often in the HMD group (28%). Trends in survival rates over the study period are discussed as are measurements for improvements.

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

EVALUATION OF MECHANICAL VENTILATION IN NEWBORN INFANTS: I. Techniques and survival rates

et al. 1980

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“…Hyperventilation is normal in pregnancy (Reid et al, 1967), the diaphragm is raised (McGinty, 1938), pulmonary diffusing capacity may be lower (Bedell and Adams, 1962), and expiratory reserve volume, residual volume, and mean functional residual capacity are all reduced in the third trimester (Gaensler, 1965). The reduction of expiratory reserve volume in pregnancy may be related to the susceptibility of pregnant patients to a postural influence on Po2, as it has been shown that ventilation perfusion abnormalities occur in obese non-pregnant subjects and that this bears a relation to the expiratory reserve volume and can reduce arterial Pa2 during resting tidal ventilation (Holley et al, 1967).…”

Section: Mediclj203mentioning

confidence: 99%

Postural influence on maternal capillary oxygen and carbon dioxide tension

Ang¹,

Tan²,

Walters³

et al. 1969

BMJ

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“…The first evidence from randomised studies that IPPV could benefit infants came in 1961 when Wright et al [16] reported that more infants with tetanus neonatorum survived if they were treated with IPPV (14/25 vs. 4/25). In 1967, Reid et al [17] reported that more infants with respiratory distress syndrome (RDS) survived if they were randomised to IPPV than to 'a modified Usher regimen' (O 2 and IV NaHCO 3 and glucose) between 3 and 6 h of age (8/10 survivors compared to 2/10). In 1970, Murdock et al [18] reported the results of a randomised comparison of ventilation with various different machines (including a negative pressure ventilator) and supplemental ambient O 2 for 221 outborn infants with RDS.…”

Section: Respiratory Support For Extremely Preterm/elbw Infantsmentioning

confidence: 99%

‘Resuscitation’ of Extremely Preterm and/or Low-Birth-Weight Infants – Time to ‘Call It’?

O’Donnell¹

2008

Neonatology

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Since ancient times, various methods have been used to revive apparently stillborn infants; many were of dubious efficacy and had the potential to cause harm. Based largely on studies of acutely asphyxiated term animal models, clinical assessment and positive pressure ventilation have become the cornerstones of neonatal resuscitation over the last 40 years. Over the last 25 years, care of extremely preterm infants in the delivery room has evolved from a policy of indifference to one of increasingly aggressive support. The survival of these infants has improved considerably in recent years; this has not, however, necessarily been due to more aggressive resuscitation. Urban myths have evolved that all extremely preterm infants died before they were intubated, and that all such infants need to immediately intubated or they will quickly die. This has never been true. Clinical assessment of infants at birth is subjective. Also, many techniques used to support preterm infants at birth have not been well studied and there is evidence that they may be harmful. It may thus be argued that many of our well-intentioned resuscitation interventions are of dubious efficacy and have the potential to cause harm. ‘Resuscitation’ is an emotive term which means ‘restoration of life’. Death, thankfully, is a rare presentation in the delivery room. Therefore, concerning neonatal ‘resuscitation’, it is time to ‘call it’ something else. This will allow us to dispassionately distinguish preterm infants who are dead, or nearly dead, from those who are merely at high risk of parenchymal lung disease. We may then be able to refine our interventions and determine what methods of support benefit these infants most.

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A Controlled Trial of Artificial Respiration in the Respiratory-Distress Syndrome of the Newborn

Cited by 32 publications

References 9 publications

EVALUATION OF MECHANICAL VENTILATION IN NEWBORN INFANTS: I. Techniques and survival rates

EVALUATION OF MECHANICAL VENTILATION IN NEWBORN INFANTS: I. Techniques and survival rates

Postural influence on maternal capillary oxygen and carbon dioxide tension

‘Resuscitation’ of Extremely Preterm and/or Low-Birth-Weight Infants – Time to ‘Call It’?

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