A controlled study of postoperative radiotherapy for patients with completely resected nonsmall cell lung carcinoma

Dautzenberg, Bertrand; Arriagada, R.; Chammard, A. Boyer; Jarema, A; Mezzetti, M; Mattson, K.; Lagrange, J. L.; Péchoux, C. Le; Lebeau, B.; Chastang, Claude

doi:10.1002/(sici)1097-0142(19990715)86:2<265::aid-cncr10>3.0.co;2-b

Cited by 233 publications

(120 citation statements)

References 25 publications

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“…Five-year relative survival for patients with resectable disease was 32.6%, regardless of the treatment. It was 41.1% for those who underwent surgery (alone or combined with other treatments), which can be compared to the 5-year crude survival in surgical series: 40.4% for the surgery arm, with or without postoperative radiotherapy in the IALT trial (The IALT Collaborative Group, 2004), and 43% in the surgery alone arm of the post-operative radiation therapy trial (Dautzenberg et al, 1999).…”

Section: Discussionmentioning

confidence: 99%

Non-small-cell lung cancer in a French department, (1982–1997): management and outcome

Foeglé

Hédelin

Lebitasy³

et al. 2005

Br J Cancer

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Addition of chemotherapy to the treatment of non-small-cell lung cancer (NSCLC) resulted in a modest but clear improvement in the survival of selected patients. To ascertain if this translates to improved survival in the whole population of patients, we conducted a retrospective population-based study of a sample of 1738 patients diagnosed with primary NSCLC in a French department between 1982 and 1997. The proportion of women, metastatic cases and adenocarcinoma changed significantly over time, as did their management: use of chemotherapy alone increased from 9.7 to 28.1% (Po0.0001), while the use of radiotherapy alone decreased from 32.2 to 9.4% (Po0.0001). The 5-year survival probability was 15.7 % for all patients and 32.6% for those with resectable disease. The 1-and 2-year survival probabilities were 38.2 and 15.6% in locally advanced disease, and were, respectively, 16.8 and 5.2% in metastatic disease. Disease extent and histological subtype were significant independent prognostic factors. Survival of resectable disease was longer among patients treated with surgery or surgery plus chemotherapy, while better outcomes for locally advanced disease were associated with radiation plus chemotherapy. In metastastic disease, patients treated by classical agent without platin or palliative care only had the shortest survival. Despite changes in treatment in accordance with the state-of-the-art, overall survival did not improve over time. It is not unlikely that more patients with bad PS were diagnosed during the latter end of the study period. This could at least partially explain the absence of detection of an overall improvement in survival.

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Section: Discussionmentioning

confidence: 99%

Non-small-cell lung cancer in a French department, (1982–1997): management and outcome

Foeglé

Hédelin

Lebitasy³

et al. 2005

Br J Cancer

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“…Furthermore, among the locally advanced stage II to III cases, no difference was observed in the survivals of patients according to radiotherapy in the present study (data not shown). In fact, previous clinical studies also reported that radiotherapy itself has less survival benefit for NSCLC patients (Dautzenberg et al, 1999).…”

Section: Discussionmentioning

confidence: 99%

Evaluations of biomarkers associated with 5-FU sensitivity for non-small-cell lung cancer patients postoperatively treated with UFT

et al. 2006

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The sensitivity to 5-fluorouracil (5-FU) has been reported to be associated with target molecule thymidylate synthase (TS), fluoropyrimidine-metabolising enzymes such as orotate phosphoribosyltransferase (OPRT), and dihydropyrimidine dehydrogenase (DPD). We performed an immunohistochemical study on the clinical significance of TS, OPRT, and DPD expression using 151 resected non-small-cell lung cancer (NSCLC) patients postoperatively treated with a combination of tegafur and uracil (UFT). Eightytwo carcinomas were TS-positive, 105 carcinomas were OPRT-positive, 68 carcinomas were DPD-positive. No correlation was observed in the HSCORE between the TS and OPRT expression (r ¼ 0.203), between the TS and DPD expression (r ¼ 0.098), or between the OPRT and DPD expression (r ¼ 0.074). Regarding the survival of NSCLC patients treated with UFT, the 5-year survival rate of patients with TS-negative tumours was significantly higher than that with TS-positive tumours (P ¼ 0.0133). The 5-year survival rate of patients with OPRT-positive stage II to III tumours was significantly higher than that with OPRT-negative stage II to III tumours (P ¼ 0.0145). In addition, the 5-year survival rate of patients with DPD-negative tumours was also significantly higher than that with DPD-positive tumours (P ¼ 0.0004). A Cox multivariate regression analysis revealed the TS status (hazard ratio 2.663; P ¼ 0.0003), OPRT status (hazard ratio 2.543; P ¼ 0.0005), and DPD status (hazard ratio 2.840; Po0.0001) to all be significant prognostic factors for the survival of resected NSCLC patients postoperatively treated with UFT.

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“…7 The authors of that report suggested that the addition of PORT may have had an adverse effect by virtue of acute or delayed radiation effects, such as radiation pneumonitis or cardiotoxicity. Heart disease mortality accounts for the major component of late radiation-induced toxicity 8,9 ; the discrepancy between an increase in local control and a decrease in survival for patients receiving PORT warrants further investigation.…”

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confidence: 99%

The risk of death from heart disease in patients with nonsmall cell lung cancer who receive postoperative radiotherapy

Lally

Detterbeck

Geiger

et al. 2007

Cancer

106

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A range of flat hot‐compacted single‐polymer composite panels made from oriented polypropylene and polyethylene with differing dynamic modulus and damping capacity were freely suspended and subjected to mechanical excitation, allowing their acoustic frequency response over the audio bandwidth to be measured. The audio response over selected bands was correlated with the dynamic modulus and damping capacity measured in bending in these materials and compared with the response of a traditional composite material, namely, carbon‐fiber‐reinforced epoxy resin. Low damping and high dynamic modulus were found to result in relatively high output levels from the hot‐compacted flat panels, which contrasted with the results previously measured on a traditional cone‐shaped speaker made from a hot‐compacted polypropylene material, which found high damping to be advantageous. The results of the current study on flat panels are explained in terms of mechanical impedance of the panels and their corresponding efficiency. It was concluded that the best flat‐panel audio response came from compacted polyethylene sheets, which combined high stiffness, low density, and a low level of damping. © 2005 Wiley Periodicals, Inc. J Appl Polym Sci, 2006

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A controlled study of postoperative radiotherapy for patients with completely resected nonsmall cell lung carcinoma

Cited by 233 publications

References 25 publications

Non-small-cell lung cancer in a French department, (1982–1997): management and outcome

Non-small-cell lung cancer in a French department, (1982–1997): management and outcome

Evaluations of biomarkers associated with 5-FU sensitivity for non-small-cell lung cancer patients postoperatively treated with UFT

The risk of death from heart disease in patients with nonsmall cell lung cancer who receive postoperative radiotherapy

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