A controlled study of beta hemolytic streptococcal infection in rheumatic families

Miller, Joseph M.; Stancer, Samuel L.; Massell, Benedict F.

doi:10.1016/0002-9343(58)90057-3

Cited by 18 publications

(1 citation statement)

References 58 publications

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“…However, even when much higher doses (up to 4-fold) of penicillin were given, no improved GABHS eradication was achieved. [52][53][54][55][56][57][58][59][60][61][62][63][64] …”

Section: Amoxicillin Shortened Coursementioning

confidence: 99%

Antibacterial Therapy for Acute Group A Streptococcal Pharyngotonsillitis

Brook

2002

Pediatric Drugs

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The objective of this review is to examine the use of short-course antibacterial therapy of group A beta-hemolytic streptococcal (GABHS) pharyngotonsillitis, compared with traditional 10-day therapy. In preparing this paper we reviewed the medical literature of studies comparing 10 days of penicillin with shorter courses of antibacterial therapy. Short-course therapy of 6 days of amoxicillin, 4 to 5 days of cephalosporins, and 5 days of azithromycin was found to be as, or more effective than traditional 10-day penicillin therapy. The benefits of short-course therapy include superior compliance and adherence, lower incidence of adverse effects, less effect on the bacterial flora, improved patient and parent satisfaction, and lower drug costs. In conclusion, short courses of amoxicillin, cephalosporins, and macrolides provide superior or equal efficacy to a 10-day course of penicillin therapy in the treatment of GABHS pharyngotonsillitis.

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“…However, even when much higher doses (up to 4-fold) of penicillin were given, no improved GABHS eradication was achieved. [52][53][54][55][56][57][58][59][60][61][62][63][64] …”

Section: Amoxicillin Shortened Coursementioning

confidence: 99%