A Controlled Release Microsphere Formulation of an Anti-Diabetic Drug and Characterization of the Microsphere

Chakra, Biplab Kumar; Karan, Saumen; Das, Biswajit; Debnath, Souvik; Chatterjee, Tapan K.

doi:10.22159/ijpps.2018v10i10.27541

Cited by 6 publications

(5 citation statements)

References 17 publications

(14 reference statements)

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“…Microspheres containing a high concentration of the gum showed a slow release which can be related to the high viscosity of the internal aqueous phase that increased with gum concentration and alginate. However, the increment of the gum concentration had a significant impact on drug release which was retarded from 7.53 to 10.82 hours with time required for 50% of drug release (t50%) and similar trend was noticed with 80% [62].…”

supporting

confidence: 54%

The Impact of Natural and Synthetic Polymers in Formulating Micro and Nanoparticles for Anti-Diabetic Drugs

Al-Hashimi

Babenko

Saaed

et al. 2021

CDD

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: Diabetes mellitus is one of the long known chronic diseases, today over 400 million people are diagnosed with diabetes. Yet curing diabetes is a challenge. Over the decades, the approaches of treating diabetes mellitus have evolved and polymeric materials have played an integral part in developing and manufacturing anti-diabetic medications. However, injection of insulin remains the conventional therapy for the treatment of diabetes. Oral administration is generally the most preferred route; yet, physiological barriers lead to a challenge for the formulation development for oral delivery of antidiabetic peptide and protein drugs. This present review focuses on the role of different types of biodegradable polymers (e.g., synthetic and natural) that have been used to develop micro and nano particles based formulations for antidiabetic drugs (Type 1 and Type 2) and how the various encapsulation strategies impact its therapeutic effect, including pharmacokinetics studies, drug release profiles and efficacy of the encapsulated drugs. This review also includes studies of different dosage forms such as oral, nasal, inhalation and sublingual for the treatment of diabetes that have been investigated using synthetic and natural biodegradable polymers in order to develop an alternative route to subcutaneous route for a better control of serum glucose levels.

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supporting

confidence: 54%

The Impact of Natural and Synthetic Polymers in Formulating Micro and Nanoparticles for Anti-Diabetic Drugs

Al-Hashimi

Babenko

Saaed

et al. 2021

CDD

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“…To The results exhibited the possible synergistic effect when Cel and 5-FU were used in combination. This strategy could be used as a potential approach for the management of CRC due to controlled release phenomena [35,36].…”

Section: In Vitro Cytotoxicity Assaymentioning

confidence: 99%

Colon Specific Delivery of Combination of 5-Fluorouracil and Celecoxib: Preparation, Characterization, and in Vitro Cytotoxicity Assay

Bansal

Kamboj

Madan

2019

Asian J Pharm Clin Res

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Objective: 5-Fluorouracil (5-FU) and celecoxib (Cel) combination offered additive effect in the treatment of colon cancer. However, physicochemical and biopharmaceutical attributes of both drugs deliver suboptimal concentration at the site of action. The objective of the current study is the development of a microparticulate drug delivery system loaded with a combination of 5-FU and Cel to achieve prolonged drug delivery in colon cancer. Methods: 5-FU and Cel combination were loaded in Eudragit coated chitosan (CH) microspheres (MSs) and characterized. Results: The average particle size of the MSs was in the range of 2.7±0.9μm to 4.8±1.1μm. A substantial drug encapsulation efficiency of 71.30±2.3% as obtained for 5-FU as compared to 35.20±1.9% of Cel in the tailored microparticles. The drug loading capacity of 6.5 mg/10 mg and 2.3 mg/10 mg was obtained for 5-FU and Cel, respectively. By Eudragit S 100 (Ed) coating, significant pH-dependent release profile was achieved, and no drug release was observed in simulated gastric and intestinal fluids. The developed MSs exhibited the release of 92.1±2.9% of 5-FU in 8h whereas 18.9±0.7% Cel was found to be released from the developed MSs. The drug-loaded MSs exhibited appreciable potency against HT-29 cells with an IC50 value of 35.9 μM. Conclusion: The results indicated that these microparticles are a promising vehicle for selectively targeting drugs to the colon in the chemotherapy of colon cancer.

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“…The SEM photographs indicated that the gastrospheres were completely covered with polymer the rough texture which may be due to removal of water from gastrospheres during drying. Thus the rate of removal of water from gastrospheres exerts an influence on the morphology of final product [23][24][25][26][27][28].…”

Section: Scanning Electron Microscopy (Sem)mentioning

confidence: 99%

Design, Development, and Characterization of Ocimum Basilicum Mucilage-Based, Modified Release Mucoadhesive Gastrospheres of Carvedilol

FJ²

2019

Asian J Pharm Clin Res

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Objective: The present investigations aim to develop mucoadhesive gastrospheres of carvedilol using sodium alginate and Ocimum basilicum seed mucilage combination blend oral use. Methods: The gastrospheres were prepared by ionotropic gelation method using 32 factorial designs, the concentration of sodium alginate and O. basilicum mucilage was independent variables while % drug content (DC), % entrapment efficiency, and % drug release at 12 h were dependent variables. The gastrospheres were evaluated for other parameters such as Fourier-transform infrared (FTIR), powder X-ray diffraction, differential scanning calorimetric, and in vitro mucoadhesion studies. Results: In optimization studies from statistical second-order complete model equation among the polymers used O. basilicum mucilage had a more profound effect on DC and % encapsulation efficiency as compared to sodium alginate. The mean particle size of gastrospheres when measured by optical microscopy technique ranged from 774 to 882 μm. The percentage of gastrosphere adhering to goat intestinal mucosal tissue varied from 10% to 65% over 8 h in 0.1N HCl, whereas this was varied from 40% to 60% in phosphate buffer pH 6.8 with provided 12 h of controlled release following zero-order release pattern. Conclusion: Studies conclude that mucilage of O. basilicum can be used as controlled release mucoadhesive material in the formulation of gastrospheres.

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A Controlled Release Microsphere Formulation of an Anti-Diabetic Drug and Characterization of the Microsphere

Cited by 6 publications

References 17 publications

The Impact of Natural and Synthetic Polymers in Formulating Micro and Nanoparticles for Anti-Diabetic Drugs

The Impact of Natural and Synthetic Polymers in Formulating Micro and Nanoparticles for Anti-Diabetic Drugs

Colon Specific Delivery of Combination of 5-Fluorouracil and Celecoxib: Preparation, Characterization, and in Vitro Cytotoxicity Assay

Design, Development, and Characterization of Ocimum Basilicum Mucilage-Based, Modified Release Mucoadhesive Gastrospheres of Carvedilol

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