A Controlled-Release Drug Delivery System on a Chip Using Electrolysis

Recent Advances in Micro-Electro-Mechanical Devices for Controlled Drug Release Applications

“…Thirdly, the operating characteristics could be improved by selecting a more suitable material for the chamber and utilizing aluminum electrodes. They concluded that these exploding microbubbles could be very useful for electrochemical actuators and pumps of varied designs which could include specific bubble force-activated membranes (Huang et al, 2012).…”

A Comprehensive Study on Design Trends and Future Scope of Implantable Drug Delivery Systems

“…Based on the present study, control system with multiple inputs multiple outputs can be designed and tested for establishing patients" safety. An adaptive Proportional Integrator controller is proposed in [15] with an algorithm for estimating time delay for blood pressure regulation in hypertension patients.…”

“…A system on chip with integrated drug reservoirs and active circuit for drug release is presented in [15]. The microbubbles generated by electrolysis force to open drug reservoirs in order to release the drug.…”

“…Many control system designs have been proposed and implemented using proportional integrator, proportional differentiator, neural networks, and fuzzy logic [13][14][15]. The drug delivery component of IDDS is used to deliver the decided concentration of drug by controller from the drug reservoirs to the patient body.…”

Engineering of MEMS-based microfluidic devices for individualised biomedical applications

“…Further development of electrochemical actuation focused on reducing the electro-oxidization of drugs loaded in the reservoir, which may eliminate the effectiveness of the drug formulation. Li et al introduced a bellow to separate the electrolyte (DI water) and the drug solution loaded [42,44,65]. Gases were enclosed inside the bellow while at the same time pneumatic forces deflect the bellows to drive drug solutions [29,44,65].…”