1993
DOI: 10.1016/0022-3956(93)90019-x
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A controlled family study in panic disorder

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Cited by 92 publications
(40 citation statements)
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“…Weissman et al [1993] found odds ratios for panic disorder in first-degree relatives that ranged from 9.4 to 20.8, depending on whether the panic disorder in the proband and/or the relative was uncomplicated or complicated with major depressive disorder. Other family studies have found an increased familial risk, although some have been lower than those cited above [Crowe et al, 1983;Maier et al, 1993;Mendlewicz et al, 1993]. A study of panic disorder in female twins reported a probandwise MZ concordance of 23.9% compared with a DZ concordance of 10.9% for definite and probable cases [Kendler et al, 1993].…”
Section: Introductionmentioning
confidence: 90%
“…Weissman et al [1993] found odds ratios for panic disorder in first-degree relatives that ranged from 9.4 to 20.8, depending on whether the panic disorder in the proband and/or the relative was uncomplicated or complicated with major depressive disorder. Other family studies have found an increased familial risk, although some have been lower than those cited above [Crowe et al, 1983;Maier et al, 1993;Mendlewicz et al, 1993]. A study of panic disorder in female twins reported a probandwise MZ concordance of 23.9% compared with a DZ concordance of 10.9% for definite and probable cases [Kendler et al, 1993].…”
Section: Introductionmentioning
confidence: 90%
“…The same study revealed a significantly higher occurrence of MD, but not of PD or GAD, in first-degree relatives of MD patients, compared to relatives of individuals, which have never been mentally ill. First-degree relatives of GAD patients suffer significantly more often from GAD, but not from MD or PD, than first-degree relatives of healthy individuals [Noyes et al, 1987]. On the other hand, Maier et al [1993] found higher cross-prevalence rates in first-degree relatives of patients suffering from PD or MD, thereby contradicting the idea of independent segregation of these disorders. Similarly, twin studies have yielded evidence for a partial genetic overlap between anxiety disorders [e.g.…”
Section: Introductionmentioning
confidence: 91%
“…First-degree relatives of affected probands have an approximately 4-to 10-fold increased risk of the disorder compared to the general population [Crowe et al, 1983;Maier et al, 1993;Goldstein et al, 1994]. Twin studies have shown that genetic factors contribute to this familial risk, and heritability has been estimated to be approximately 32±46% [Kendler et al, 1993].…”
Section: Introductionmentioning
confidence: 97%