A controlled family study in panic disorder

Maier, Wolfgang; Lichtermann, Dirk; Minges, Jürgen; Oehrlein, Alfred; Franke, Petra

doi:10.1016/0022-3956(93)90019-x

Cited by 92 publications

(40 citation statements)

References 13 publications

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“…Weissman et al [1993] found odds ratios for panic disorder in first-degree relatives that ranged from 9.4 to 20.8, depending on whether the panic disorder in the proband and/or the relative was uncomplicated or complicated with major depressive disorder. Other family studies have found an increased familial risk, although some have been lower than those cited above [Crowe et al, 1983;Maier et al, 1993;Mendlewicz et al, 1993]. A study of panic disorder in female twins reported a probandwise MZ concordance of 23.9% compared with a DZ concordance of 10.9% for definite and probable cases [Kendler et al, 1993].…”

Section: Introductionmentioning

confidence: 90%

Genomewide survey of panic disorder

et al. 2001

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We completed a genome scan of 23 multiplex families of panic disorder. Ninety family members had DSM-III-R panic disorder, and another 23 had recurrent, spontaneous panic attacks that did not satisfy these criteria. We typed 469 markers from the CHLC map (ver 8c7) with an average intermarker distance of 10.3 cM. Two-point lod scores were calculated with both a dominant and a recessive model, and maps of lod scores < -2.00, assuming genetic homogeneity, were constructed by using DSM-III-R panic disorder as the affected phenotype. Lod scores were < -2.00 over 94-95% of the genome. The greatest lod score was 2.23 (theta = 0.15) at the D7S2846 locus, located at 57.8 cM on chromosome 7 according to the Marshfield Clinic map. Flanking markers analyzed in a nonparametric, multipoint analysis using GENEHUNTER resulted in an NPL score of 2.97 at 63 cM on the Marshfield map. This region lies within 15 cM from the D7S435 locus, where Knowles et al. [1998] obtained a lod score of 1.71 (theta = 0.10) for panic disorder (now 2.45 with the addition of new families; James Knowles, personal communication). Thus, the maximum evidence of linkage from two genome scans of panic disorder lies within a small region of chromosome 7p.

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Section: Introductionmentioning

confidence: 90%

Genomewide survey of panic disorder

et al. 2001

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“…The same study revealed a significantly higher occurrence of MD, but not of PD or GAD, in first-degree relatives of MD patients, compared to relatives of individuals, which have never been mentally ill. First-degree relatives of GAD patients suffer significantly more often from GAD, but not from MD or PD, than first-degree relatives of healthy individuals [Noyes et al, 1987]. On the other hand, Maier et al [1993] found higher cross-prevalence rates in first-degree relatives of patients suffering from PD or MD, thereby contradicting the idea of independent segregation of these disorders. Similarly, twin studies have yielded evidence for a partial genetic overlap between anxiety disorders [e.g.…”

Section: Introductionmentioning

confidence: 91%

Association of a MAOA gene variant with generalized anxiety disorder, but not with panic disorder or major depression

Tadić

Rujescu

Szegedi

et al. 2002

American J of Med Genetics Pt B

103

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This study was conducted to detect a possible association of a T941G single nucleotide polymorphism (SNP) in the monoamine oxidase A (MAOA) gene with generalized anxiety disorder (GAD), panic disorder (PD), or major depression (MD). Fifty GAD patients (34 females and 16 males), 38 PD patients (21 females and 17 males), and 108 MD patients (80 females and 28 males) were included. The comparison group consisted of 276 (132 females and 144 males) unrelated healthy individuals. The 941T allele was over-represented in patients suffering from GAD (chi(2) = 6.757; df = 1; P < 0.01, not corrected for multiple testing) when compared to healthy volunteers. No association was observed in MD or PD. This is the first study specifically analyzing the MAOA G941T polymorphism in GAD and thus needs to be replicated in an independent sample. However, the results are in line with previous data suggesting an association between the MAOA locus and regulation of complex human behavior.

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“…First-degree relatives of affected probands have an approximately 4-to 10-fold increased risk of the disorder compared to the general population [Crowe et al, 1983;Maier et al, 1993;Goldstein et al, 1994]. Twin studies have shown that genetic factors contribute to this familial risk, and heritability has been estimated to be approximately 32±46% [Kendler et al, 1993].…”

Section: Introductionmentioning

confidence: 97%

Targeted genome screen of panic disorder and anxiety disorder proneness using homology to murine QTL regions

et al. 2001

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Family and twin studies have indicated that genes influence susceptibility to panic and phobic anxiety disorders, but the location of the genes involved remains unknown. Animal models can simplify gene-mapping efforts by overcoming problems that complicate human pedigree studies including genetic heterogeneity and high phenocopy rates. Homology between rodent and human genomes can be exploited to map human genes underlying complex traits. We used regions identified by quantitative trait locus (QTL)-mapping of anxiety phenotypes in mice to guide a linkage analysis of a large multiplex pedigree (99 members, 75 genotyped) segregating panic disorder/agoraphobia. Two phenotypes were studied: panic disorder/agoraphobia and a phenotype ("D-type") designed to capture early-onset susceptibility to anxiety disorders. A total of 99 markers across 11 chromosomal regions were typed. Parametric lod score analysis provided suggestive evidence of linkage (lod = 2.38) to a locus on chromosome 10q under a dominant model with reduced penetrance for the anxiety-proneness (D-type) phenotype. Nonparametric (NPL) analysis provided evidence of linkage for panic disorder/agoraphobia to a locus on chromosome 12q13 (NPL = 4.96, P = 0.006). Modest evidence of linkage by NPL analysis was also found for the D-type phenotype to a region of chromosome 1q (peak NPL = 2.05, P = 0.035). While these linkage results are merely suggestive, this study illustrates the potential advantages of using mouse gene-mapping results and exploring alternative phenotype definitions in linkage studies of anxiety disorder.

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A controlled family study in panic disorder

Cited by 92 publications

References 13 publications

Genomewide survey of panic disorder

Genomewide survey of panic disorder

Association of a MAOA gene variant with generalized anxiety disorder, but not with panic disorder or major depression

Targeted genome screen of panic disorder and anxiety disorder proneness using homology to murine QTL regions

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