A controlled crossover study to assess the role of dietary eliminations in reducing the severity of atopic dermatitis in children

Mathew, Pretty; Sridharan, Rajiv; Thyvalappil, Anoop; Sreenivasan, Ajayakumar

doi:10.4103/ijpd.ijpd_20_18

Cited by 3 publications

(2 citation statements)

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“…The majority of intervention studies focused on the younger population (age <18 years), with a total of fifty-four articles directed toward understanding and managing AD within the pediatric population [70‒122] (Table 4). There were a considerable number of studies investigating probiotic and prebiotic supplementation in pediatrics ( n = 30).…”

Section: Resultsmentioning

confidence: 99%

“…For vitamin supplementation, vitamin D3 (n = 12) [70][71][72][73][74][75][76][77][78][79][80] was exclusively studied in the pediatric population, while investigations on dietary fats (n = 4) explored γ-linolenic acid [81,82], docosahexaenoic acid [83,84], and arachidonic acid [83]. Studies on diet-related approaches (n = 5) involved avoidance of monosodium glutamate [118], eggs [120,122] and/or cow's milk [120], supplementation with whey or casein [121], and selected foods consumption [119]. These interventions [120][121][122], however, showed limited improvement in disease severity.…”

Section: Pediatric Populationmentioning

confidence: 99%

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Dietary Interventions in Atopic Dermatitis: A Comprehensive Scoping Review and Analysis

Lim,

Liu,

Chew

2024

Int Arch Allergy Immunol

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Background: This scoping review aims to critically assess gaps in the current literature on atopic dermatitis (AD) by evaluating the overall effectiveness of dietary interventions. Through a comprehensive analysis that follows the Preferred Reporting Item for Systematic Review and Meta-Analyses Extension for Scoping Reviews (PRISMA-ScR) guidelines, we conducted a thorough search on the Web of Science database in May 2023 using specific search strategies to identify all relevant studies on the research topic. Summary: A total of 104 full-text articles were included for review. Our synthesis identified seven notable categories of dietary interventions for AD, showcasing the diversity of interventions utilized. This includes vitamin supplementation, probiotic and prebiotic supplementation, dietary fat, biological compounds, foods from natural sources, major nutrients, and diet-related approaches. Further analyses stratified by targeted populations revealed a predominant focus on pediatrics, particularly in probiotic supplementation, and on adults, with an emphasis on vitamin D and E supplementation. Key Messages: Despite most dietary interventions demonstrating overall effectiveness in improving AD severity and its subjective symptoms, several significant gaps were identified. There was a scarcity of studies on adults and whole-diet interventions, a prevalence of short-term interventions, heterogeneity in study outcomes, designs, and population, occasional disparity between statistical significance and clinical relevance, and a lack of a comprehensive multidisciplinary approach. Nonetheless, these findings offer valuable insights for future AD research, guiding additional evidence-driven dietary interventions and informing healthcare professionals, researchers, and individuals, advancing both understanding and management of AD.

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Section: Resultsmentioning

confidence: 99%

Section: Pediatric Populationmentioning

confidence: 99%

Dietary Interventions in Atopic Dermatitis: A Comprehensive Scoping Review and Analysis

Lim,

Liu,

Chew

2024

Int Arch Allergy Immunol

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Unraveling the diet-dermatitis connection: A systematic review of dietary exclusion in children with atopic dermatitis

Msuya,

Srivastava

2024

CSDM

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This review focuses on atopic dermatitis (AD) impacting 10–30% of children and influenced by food and aeroallergens. It highlights the need for cautious interpretation of sensitization to foods, as it does not guarantee allergy and the potential harm of indiscriminate avoidance affecting nutrient intake. Tests such as skin prick tests, serum-specific immunoglobulin E tests, and food challenges are essential before implementing food elimination. The objective is to assess current dietary exclusion practices in AD children. By screening eight studies including randomized controlled trials, systematic reviews, and cohort studies, the review underscores the benefits of evidence-based dietary exclusion for moderate to severe cases. It establishes causal links between food allergy (FA) and AD emphasizing evidence-based dietary modification over blanket elimination. Temporal changes in allergen antigenicity also suggest evidence-based, supervised practices. In conclusion, the review supports the benefits of evidence-guided food exclusion for AD with 50% of studies backing moderate-to-severe cases. It highlights the need for robust trials to guide rational food restriction, ultimately aiding patients and parents.

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A Study of Sleep Quality and Quality of Life in Children with Atopic Dermatitis between 6 and 12 Years of Age

Kallan,

Pillai,

Hijaz

et al. 2023

Indian Journal of Paediatric Dermatology

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Introduction: Atopic dermatitis (AD) is a common, chronic, relapsing dermatitis, affecting mainly children. It is associated with intense pruritus which can disrupt the sleep and quality of life (QOL), thereby impairing the neurocognitive development. An understanding of the link between severity of AD and sleep quality in children may help in better treatment of this condition. Materials and Methods: A hospital-based cross-sectional study was conducted to correlate severity of AD with sleep quality and QOL. Sixty-six children with AD were enrolled for the study. In addition to basic demographic details, all patients were analyzed for disease severity using SCORing AD (SCORAD) score. The QOL and sleep quality were evaluated using Children’s Dermatology Life Quality Index (CDLQI) questionnaire and Children’s Sleep Habits Questionnaire (CSHQ), respectively. Results: The mean age of the study group was 8.94 ± 1.94 years and mean body mass index was 19.97 ± 2.69 kg/m2. The median SCORAD score was 32 ± 50. Mean CSHQ score was 43.17 ± 7.15, and it showed a positive correlation with SCORAD score (R 2 = 0.655; P = 0.000). Similarly, median score of CDLQI was 14 ± 18, which also showed a positive correlation with SCORAD score (R 2 = 0.822; P = 0.000). All the domains of CDLQI questionnaire were affected by the disease. In the CSHQ questionnaire, all parameters were affected except parasomnias and sleep-disordered breathing. Conclusion: The study demonstrated a significant association between severity of AD with sleep quality and QOL. It highlights the need for interventions to diminish sleep problems and to improve QOL in children with AD.

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A controlled crossover study to assess the role of dietary eliminations in reducing the severity of atopic dermatitis in children

Cited by 3 publications

References 0 publications

Dietary Interventions in Atopic Dermatitis: A Comprehensive Scoping Review and Analysis

Dietary Interventions in Atopic Dermatitis: A Comprehensive Scoping Review and Analysis

Unraveling the diet-dermatitis connection: A systematic review of dietary exclusion in children with atopic dermatitis

A Study of Sleep Quality and Quality of Life in Children with Atopic Dermatitis between 6 and 12 Years of Age

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