A controlled clinical trial on the effects of exercise on neuropsychiatric disorders and instrumental activities in women with Alzheimer's disease

Nascimento, Carla Manuela Crispim; Teixeira, Camila Vieira Ligo; Gobbi, Lílian Teresa Bucken; Gobbi, Sebastião; Stella, Florindo

doi:10.1590/s1413-35552012005000017

Cited by 36 publications

(48 citation statements)

References 53 publications

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“…In line with this, Nascimento et al . confirmed the benefits of physical exercise in IADL in a sample of AD patients . PD patients also presenting cognitive impairments that are associated with the disease progression frequently develop dementia as a result of an imbalance of the dopaminergic and cholinergic circuits in the brain .…”

Section: Discussionmentioning

confidence: 55%

“…In line with this, Nascimento et al confirmed the benefits of physical exercise in IADL in a sample of AD patients. 51 PD patients also presenting cognitive impairments that are associated with the disease progression frequently develop dementia as a result of an imbalance of the dopaminergic and cholinergic circuits in the brain. 4 Despite the global cognitive decline, frontal lobe dysfunctions are common in patients with PD, mainly affecting executive functions and resulting in impaired ability to plan and impaired thinking flexibility, and having selective attention, 5 52 Past studies have linked the performance of IADL to cognitive impairment and executive dysfunction; 53,54 thus, a probable explanation for these gains in this specific functional dimension could be related to an improvement in cognitive and executive functions.…”

Section: Discussionmentioning

confidence: 99%

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Effect of a multimodal exercise program on sleep disturbances and instrumental activities of daily living performance on Parkinson's and Alzheimer's disease patients

Nascimento

Ayán

Gobbi

et al. 2013

Geriatrics Gerontology Int

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Section: Discussionmentioning

confidence: 55%

Section: Discussionmentioning

confidence: 99%

Effect of a multimodal exercise program on sleep disturbances and instrumental activities of daily living performance on Parkinson's and Alzheimer's disease patients

Nascimento

Ayán

Gobbi

et al. 2013

Geriatrics Gerontology Int

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“…recent Cochrane Review concluded that exercise studies on neuropsychiatric symptoms, which were able to show a similar effect, were of insufficient quality [9] though, in that review, some previous low intensity or multimodal intervention studies were suggestive that exercise improved neuropsychiatric symptoms [31,32]. Our findings indicate that physical exercise may inhibit or delay the emergence of more severe neuropsychiatric symptoms with disease progression.…”

Section: Discussionmentioning

confidence: 64%

Moderate-to-High Intensity Physical Exercise in Patients with Alzheimer’s Disease: A Randomized Controlled Trial

Hoffmann

Sobol

Frederiksen

et al. 2016

JAD

242

260

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Abstract.Background: Studies of physical exercise in patients with Alzheimer's disease (AD) are few and results have been inconsistent. Objective: To assess the effects of a moderate-to-high intensity aerobic exercise program in patients with mild AD. Methods: In a randomized controlled trial, we recruited 200 patients with mild AD to a supervised exercise group (60-min sessions three times a week for 16 weeks) or to a control group. Primary outcome was changed from baseline in cognitive performance estimated by Symbol Digit Modalities Test (SDMT) in the intention-to-treat (ITT) group. Secondary outcomes included changes in quality of life, ability to perform activities of daily living, and in neuropsychiatric and depressive symptoms. Results: The ITT analysis showed no significant differences between intervention and control groups in change from baseline of SDMT, other cognitive tests, quality of life, or activities of daily living. The change from baseline in Neuropsychiatric Inventory differed significantly in favor of the intervention group (mean: -3.5, 95% confidence interval (CI) -5.8 to -1.3, p = 0.002). In subjects who adhered to the protocol, we found a significant effect on change from baseline in SDMT as compared with the control group (mean: 4.2, 95% CI 0.5 to 7.9, p = 0.028), suggesting a dose-response relationship between exercise and cognition. * Correspondence to: Professor, DMSc, MD, Steen G. K. Hoffmann et al. / Aerobic exercise in Alzheimer's diseaseConclusions: This is the first randomized controlled trial with supervised moderate-to-high intensity exercise in patients with mild AD. Exercise reduced neuropsychiatric symptoms in patients with mild AD, with possible additional benefits of preserved cognition in a subgroup of patients exercising with high attendance and intensity.

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“…Corroborating these results, the literature presents similar studies 13,22 . Nascimento et al 23 carried out a study with MPT for 24 weeks and observed that the TG showed reduction in the neuropsychiatric symptoms of AD, increasing the global cognitive functions and improving the ability to perform daily activities.…”

Section: Discussionmentioning

confidence: 99%

Treinamento físico multimodal com dupla tarefa na doença de Alzheimer: efeito nas funções cognitivas e na força muscular

Ferreira

Lopes

Henriques

et al. 2017

Rev. Bras. Cineantropom. Desempenho Hum.

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The aim of this study was to evaluate the effects of dual task multimodal physical training (MPT) on the cognitive functions and muscle strength in older adults with Alzheimer’s disease. Participants were 19 subjects with AD in the mild and moderate stages, divided into training group (TG) and control group (CG). The TG performed dual task MPT for 12 weeks. Subjects were evaluated at the pre- and post-intervention moments. The Mini Mental State Examination (MMSE), Clock Drawing Test (CDT) and Frontal Assessment Battery (FAB) were used to assess cognition. For muscle strength, the Chair Lift and Sit Test (CLST) and Manual Grasp Force (MGF) were used. The Wilcoxon test was used to analyze pre and post intragroup moments. The TG showed a significant improvement in FAB and CLST (p≤0.05) and a tendency to improve the MMSE score (p≤0.08). The CG showed significant improvement in CLST (p≤0.05). Dual task MPT improves the frontal cognitive functions and lower limb muscle strength of older adults with AD.

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A controlled clinical trial on the effects of exercise on neuropsychiatric disorders and instrumental activities in women with Alzheimer's disease

Cited by 36 publications

References 53 publications

Effect of a multimodal exercise program on sleep disturbances and instrumental activities of daily living performance on Parkinson's and Alzheimer's disease patients

Effect of a multimodal exercise program on sleep disturbances and instrumental activities of daily living performance on Parkinson's and Alzheimer's disease patients

Moderate-to-High Intensity Physical Exercise in Patients with Alzheimer’s Disease: A Randomized Controlled Trial

Treinamento físico multimodal com dupla tarefa na doença de Alzheimer: efeito nas funções cognitivas e na força muscular

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