A controlled assessment of an asthma self-management plan involving a budesonide dose regimen. OPTIONS Research Group

Ayres, Jon G.; Campbell, L. M.

doi:10.1183/09031936.96.09050886

Cited by 36 publications

(18 citation statements)

References 6 publications

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“…Reflux symptoms included heartburn, regurgitation, dysphagia, belching and hoarseness and were graded similarly. This asthma symptom scale has been used in previous studies [27][28][29] . Randomization was done after initial screening and all patients received white capsules containing omeprazole 20 mg (Ome; Dr. Reddy's Laboratories; Hyderabad, India) to be taken orally 1 h before breakfast and 1 h before the evening meal and domperidone (Dom; Dr. Reddy's Laboratories, Hyderabad, India) 10 mg orally 3 times daily (1 h before breakfast, lunch and evening meal) or identical placebo capsules (1:1 double-blind randomization).…”

Section: Methodsmentioning

confidence: 99%

Effect of omeprazole and domperidone on adult asthmatics with gastroesophageal reflux

Sharma

Sharma²,

Daga³

et al. 2007

WJG

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AIM:To study the effect of combined omeprazole (Ome) and domperidone (Dom) therapy on asthma symptoms and pulmonary function in asthmatics with gastroesophageal reflux. METHODS:We selected 198 asthmatics with gastroesophageal reflux diagnosed by 24-h esophageal pH monitoring to receive Ome 20 mg twice daily and Dom 10 mg three times daily or placebo for 16 wk (1:1 double-blind randomization). Spirometry was done at baseline and after 16 wk of treatment. The primary outcome measures were: mean daily daytime and nighttime asthma symptom scores. Mean daily reflux symptom scores, albuterol use as rescue medication (number of puffs), daytime and nighttime peak expiratory flow rate (PEFR), postbronchodilator forced expiratory volume in 1 second (FEV1) and postbronchodilator forced vital capacity (FVC) were secondary outcome measures. RESULTS:Comparison of mean change from baseline between antireflux therapy and placebo groups revealed significant reduction in daytime asthma symptom score (17.4% vs 8.9%), nighttime asthma symptom score (19.6% vs 5.4%), reflux symptom score (8.7% vs 1.6%) and rescue medication use (23.2% vs 3.1%) after antireflux therapy compared to mean change in placebo group (P < 0.001). There was significant improvement in morning PEFR (7.9% vs 0.2%), evening PEFR (9.8% vs 0.5%), FEV1 (11.1% vs 3.78%) and FVC (9.3% vs 1.52%) in the antireflux therapy group compared to placebo on comparing the mean change from baseline after 16 wk (P < 0.01). CONCLUSION:Combined therapy with Ome and Dom in adult asthmatics with gastroesophageal reflux may be beneficial by reducing asthma symptoms, rescuing medication use, and improving pulmonary function.

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Section: Methodsmentioning

confidence: 99%

Effect of omeprazole and domperidone on adult asthmatics with gastroesophageal reflux

Sharma

Sharma²,

Daga³

et al. 2007

WJG

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“…Furthermore, it is unlikely to be undertaken by the patient, even if recommended. An alternative approach is for patients with mild asthma to have a simple regimen in which the dose of inhaled corticosteroid therapy is adjusted by the physician at clinic visits, an approach which may be easier to follow [26].…”

Section: Benefits For Specific Patient Groupsmentioning

confidence: 99%

The use of the self-management plan system of care in adult asthma

Holt¹,

Masoli

Beasley

2004

Primary Care Respiratory Journal

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KEYWORDS Asthma self-management plans;Asthma action plans; Asthma managementSummary The development of self-management plans arose as clinicians tried to design better methods by which they could deliver asthma care and reduce the significant mortality and morbidity associated with this disease. The basic principles that resulted have been widely endorsed, and self-management plans are now recommended in the long-term management of adult asthma. Self-management plans essentially focus on the early recognition of unstable or deteriorating asthma, by monitoring peak flow or symptoms. Through the use of written guidelines, patients are then able to determine when it is necessary to adjust therapy or obtain medical assistance.There is now convincing evidence that the use of self-management plans by patients with asthma leads to a marked reduction in morbidity and a reduced requirement for acute medical treatment including hospital admissions. Recent research has also clarified many of the different issues concerning their structure and implementation. In some respects the skill in the use of the asthma self-management plan system of care is the ability to modify the standard plans to meet the particular needs of the individual asthmatic patient, including their preferences.

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“…The study by AYRES et al [5] in this issue of the Journal provides additional evidence of efficacy of a management plan based on peak flow monitoring and inhaled corticosteroid therapy. Both treatment groups regularly recorded peak flow rates, with their inhaled corticosteroid therapy modified in accordance with changes in peak flow, which was undertaken either by the patient at home, or by the doctor on regular clinic review.…”

Section: Efficacy Of Peak Flow-based Management Plansmentioning

confidence: 99%

“…In many respects, the real importance of the study by AYRES et al [5] is the contribution it makes to our understanding of this issue.…”

Section: Structure Of a Peak Flow-based Self-management Planmentioning

confidence: 99%

“…In this editorial, we briefly review the studies on which the current recommendations are based, and comment on three articles published in this edition of the European Respiratory Journal, which provide valuable additional knowledge in this area [3][4][5]. Finally, we attempt to bring together the published literature to propose practical and simple guidelines for the use of peak flow-based selfmanagement plans by adult asthmatic patients.…”

Section: Editorialmentioning

confidence: 99%

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