A Contribution to the Problem of the Mechanism of Cobalt Polycythæmia

Wesley, I

doi:10.3109/13813455109144972

Cited by 6 publications

(2 citation statements)

References 5 publications

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“…The experimental evidence presented in this work, however, clearly shows that this was not the case. The finding in the present series of experiments that methylene blue did not counteract the cobalt effect is at variance with previously published results by Wesley (1951). It indicates that even though methylene blue may restore the electron transport through the oxidative pathway this does not obliterate the cobalt effect.…”

Section: Discussionsupporting

confidence: 57%

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A Comparison of the Cobalt, Methylene Blue, Zinc, Arsenite and Amino Triazole Effect on Erythropoietin Production

1973

Br J Haematol

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The possible mechanisms of action of cobalt in stimulating erythropoietin production are considered.It is demonstrated that although arsenite shares some ofits biochemical effects with cobalt, it does not stimulate the production of erythropoietin. It has been claimed previously that methylene blue could prevent the development of erythrocytosis after cobalt. In the present series of experiments, however, methylene blue did not affect the production of erythropoietin after injection of cobalt to rabbits.

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Section: Discussionsupporting

confidence: 57%

“…Experiments by Wesley (1951) suggest that the erythropoiesis stimulating effect of cobalt could be nullified by simultaneous administration of methylene blue to rabbits. As this observation might be a clue to the mode of action of cobalt, it was attempted to repeat these experiments with a demonstration of the effect on erythropoietin production.…”

mentioning

confidence: 99%