A continuous registration method in experimental arterial thrombosis in the rat

The Inhibition of PGI₂ Synthetase within the Arterial Wall by 15-Hydroperoxyarachidonic Acid Enhances Local White Platelet Thrombosis

“…In a standardized in vivo model (5) for the study of arterial thrombus for mation, we demonstrated that topical superfusion of the investigated arterial segment with inhibitors of cyclooxygenase such as ASA and indomethacin (1) or flurbiprofen (4) resulted in a significant decrease of white platelet thrombus formation induced by ADP superfusion (5) following focal desendothelialization (9) by means of electrical current application.…”

Role of the Prostaglandin Biochemical Pathway in Platelet-Vessel Wall Interaction and Local Thrombosis

“…The technical details concern ing the operative procedure, the induction of focal desendothelialization, and the methodology for the electronically controlled microprojection procedure have been previously described [5], Briefly summa rized, this method consists in the microprojection in dark room of the electrically treated arterial segment onto a set of 30 light-depending-resistances (LDR) arranged in two columns of 15 elements. An LDR ele ment has the property to change its internal resistance in function of variations in light intensity.…”

“…Topical superfusion of this arterial segment with a solution of adenosine diphosphate (ADP) re sults in adhesion of platelets onto the desqua mated area followed by local thrombus for mation. These phenomena were evidenced by electronically processed microprojection [5] and ultrastructural controls [6].…”

Endothelial Injury and Platelet Thrombosis in Mesenteric Arteries of Rats: A Scanning Electron Microscopy Study

“…Both methods apply to vessels with an inter nal diameter exceeding 1 mm. In smaller ves sels, intimal lesions can be induced by the application of an electric microcurrent [Bourgain and Six, 1974] or a laser beam [Kovacs andGorog, 1979;Weichert et al, 1983] to the external vessel wall.…”