A Contemporary Update on Pathology Standards for Bladder Cancer: Transurethral Resection and Radical Cystectomy Specimens

Hansel, Donna E.; Amin, Mahul B.; Compérat, Éva; Côté, Richard J.; Knüchel, Ruth; Montironi, Rodolfo; Reuter, Victor E.; Soloway, Mark S.; Umar, Saleem A.; Kwast, Theodorus H. van der

doi:10.1016/j.eururo.2012.10.008

Cited by 118 publications

(75 citation statements)

References 83 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…As a result of sampling error and tumor heterogeneity, transurethral resection (TUR) has been reported to detect only 39% of variant cancers that present within the bladder. 4,5 Adding to the inherent difficulty with detection, it has been estimated that up to 44% of cases of histologic variants are not recognized or documented by community pathologists, which further leads to underreporting and the potential for mismanagement of patients. Initial reports also suggested that variant tumors were uniformly present at a high stage with invasion into muscularis propria.…”

Section: Challenges In the Study Of Variant Histologymentioning

confidence: 98%

“…In an effort to combat these challenges, many groups are attempting to outline standards and guidelines formally to aid in the identification and reporting of variant histology. 5 With the incorporation of collaborative efforts and centralized pathologic review, it is hoped that a better understanding of variant bladder cancer will result.…”

Section: Challenges In the Study Of Variant Histologymentioning

confidence: 99%

See 1 more Smart Citation

Nonurothelial Bladder Cancer and Rare Variant Histologies

Willis

Kamat

2015

Hematology/Oncology Clinics of North America

View full text Add to dashboard Cite

Section: Challenges In the Study Of Variant Histologymentioning

confidence: 98%

Section: Challenges In the Study Of Variant Histologymentioning

confidence: 99%

Nonurothelial Bladder Cancer and Rare Variant Histologies

Willis

Kamat

2015

Hematology/Oncology Clinics of North America

View full text Add to dashboard Cite

“…Pathological staging and grading were assigned according to the 7th American Joint Committee on Cancer (AJCC)/ TNM staging system 5 Pathology review impacts clinical management of patients with T1-T2 bladder cancer impact of pathology review on bladder cancer management bladder tumour (TURBT) pathology reporting 8,9 and included the revised histological diagnosis, T stage, grade, presence of muscularis propria in the specimen, LVI, and CIS. Involvement of prostatic tissue and presence of variant histology (VH) were commented on if found.…”

Section: Methodsmentioning

confidence: 99%

Pathology review impacts clinical management of patients with T1‒T2 bladder cancer

Traboulsi

Brimo

Yang

et al. 2017

CUAJ

View full text Add to dashboard Cite

Introduction: We sought to evaluate the contemporary role of a pathology review on management implications of patients with bladder cancer. Methods: A total of 98 consecutive specimens from transurethral resections in patients with suspected bladder tumours were reviewed at our institution by genitourinary pathologist. Patients were classified into risk groups according to pathology reports obtained before and after review. A management course was proposed according to local institutional practice patterns and main urological guidelines. Results: Overall, 34.7% of pathological reviews had significant changes associated with management implications, the majority of which were due to changes in risk category (and/or stage). On review pathology, 12 patients were recommended radical cystectomy instead of conservative management and two patients avoided radical cystectomy. Six patients initially staged as T1 and whose staging did not change after review had a proposed change in management in the form of early cystectomy as a treatment option, as they were deemed very high-risk secondary to high-risk features (such as carcinoma in situ or lymphovascular invasion found on review). Ten patients initially staged as T2 demonstrated high-risk features on review. Conclusions: Review by genitourinary pathologist remains important, as it defines more clearly the tumour risk category and influences the management of T1-T2 bladder cancer patients. A complete initial pathological report has the potential to further decrease the discrepancy between initial and review reports.

show abstract

“…Bladder muscle in the resection biopsies is mandatory for correct staging. (19,20). With larger tumors, the resection is performed in 3 levels: the exophytic part, the tumor base with underlying muscular layer and the edge of the resection area.…”

Section: Transurethral Resectionmentioning

confidence: 99%

Staging and tumor biological mechanisms of lymph node metastasis in invasive urinary bladder cancer

Aljabery¹

2017

Linköping University Medical Dissertations

View full text Add to dashboard Cite

Aim: To study the possibility of detecting lymph node metastasis in locally advanced urinary bladder cancer (UBC) treated with radical cystectomy (RC) by using preoperative positron emission tomography/computed tomography (PET/CT) and peroperative sentinel node biopsy (SNB) technique. We also investigate the clinical significance of macrophage traits expression by cancer cells, M2-macrophage infiltration (MI) in tumor stroma and the immunohistochemical expression of biomarkers in cancer cells in relation to clinico-pathologic data. Patients and Methods:We studied prospectively 122 patients with UBC, pathological stage pT1-pT4 treated with RC and pelvic lymph node dissection (PLND) during [2005][2006][2007][2008][2009][2010][2011] at the Department of Urology, Linköping University Hospital. In the first study, we compared the results of preoperative PET/CT and conventional CT with the findings of postoperative histopathological evaluation of lymph nodes (LNs). In the second study we investigated the value of SNB technique for detecting pathological LNs during RC in patients with UBC. We also examined the significance of the primary tumor location in the bladder in predicting the site of LN metastases, and the prognostic significance of lympho-vascular invasion (LVI) and lymph node metastasis density (LNMD) on survival. In the third study, we investigate the clinical significance of macrophage infiltration (MI) in tumor stroma and macrophage-traits expression by tumor cells. In the fourth study, we investigate the cell cycle suppression pro-

show abstract

A Contemporary Update on Pathology Standards for Bladder Cancer: Transurethral Resection and Radical Cystectomy Specimens

Cited by 118 publications

References 83 publications

Nonurothelial Bladder Cancer and Rare Variant Histologies

Nonurothelial Bladder Cancer and Rare Variant Histologies

Pathology review impacts clinical management of patients with T1‒T2 bladder cancer

Staging and tumor biological mechanisms of lymph node metastasis in invasive urinary bladder cancer

Contact Info

Product

Resources

About