A contemporary review on pathogenesis and immunity of COVID-19 infection

Mirzaei, Rasoul; Karampoor, Sajad; Sholeh, Mohammad; Moradi, Pouya; Ranjbar, Reza; Ghasemi, Faezeh

doi:10.1007/s11033-020-05621-1

Cited by 41 publications

(34 citation statements)

References 92 publications

(128 reference statements)

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“…The pathogenesis of Coronavirus disease 2019 (COVID-19), a disease that harvested more than eight hundred thousand lives today, the 27 th of August 2020 [COVID-19 Dashboard by the Center for Systems Science and Engineering (CSSE) at Johns Hopkins University], is still not completely understood and a better understanding of the pathogenesis would eventually lead to improvement in the treatment protocols as well as the control of this pandemic [ 1 ].…”

Section: Introductionmentioning

confidence: 99%

Early use of non-steroidal anti-inflammatory drugs in COVID-19 might reverse pathogenesis, prevent complications and improve clinical outcomes

Kelleni

2021

Biomedicine & Pharmacotherapy

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Section: Introductionmentioning

confidence: 99%

Early use of non-steroidal anti-inflammatory drugs in COVID-19 might reverse pathogenesis, prevent complications and improve clinical outcomes

Kelleni

2021

Biomedicine & Pharmacotherapy

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“…The mechanisms of viral infection and replication are better characterized [ 4 ] also because the scientists have profited from previous knowledge on similar viruses. The passage from the cytopathic level to the alteration of tissue structure is again less understood, although is widely acknowledged that a key role is played by local and general immunologic mechanisms [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

The use of positive end expiratory pressure in patients affected by COVID-19: Time to reconsider the relation between morphology and physiology

Perchiazzi

Pellegrini

Chiodaroli

et al. 2020

Best Practice & Research Clinical Anaesthesiology

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Coronavirus disease 2019 (COVID-19) is a new disease with different phases that can be catastrophic for subpopulations of patients with cardiovascular and pulmonary disease states at baseline. Appreciation for these different phases and treatment modalities, including manipulation of ventilatory settings and therapeutics, has made it a less lethal disease than when it emerged earlier this year. Different aspects of the disease are still largely unknown. However, laboratory investigation and clinical course of the COVID-19 show that this new disease is not a typical acute respiratory distress syndrome process, especially during the first phase. For this reason, the best strategy to be applied is to treat differently the single phases and to support the single functions of the failing organs as they appear.

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“…Considering that type L is more prevalent (70%) than type S (30%), it can be concluded that type S is the ancestral version [12]. Although considerable research improvements have occurred, the virus origin is yet obscure [13].…”

Section: Introductionmentioning

confidence: 99%

A Review on Biochemical and Immunological Biomarkers used for Laboratory Diagnosis of SARS-CoV-2 (COVID -19)

Ranjbar¹,

Hosseini²,

Dehkordi³

2020

TOMICROJ

Self Cite

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COVID-19 caused by SARS-CoV-2 is considered an emerging disease that results in severe acute respiratory syndrome. Coronaviruses, as single-stranded RNA viruses, have envelope and positive-sense genome. Virion’s nucleocapsid contains genomic RNA and phosphorylated nucleocapsid protein, which is located within the phospholipid layers and is covered with spike proteins. Although considerable research improvements have occurred, the virus origin is yet obscure. There are several factors that contribute to the development of COVID-19, such as mutations, viral loads, and the survival of the virus in the laboratory, or related factors such as age, sex, and immune status. Proper diagnosis of changes in biochemical and immunological factors affecting COVID-19 leads to the rapid detection of this disease. Finding suitable biochemical and immunological biomarkers could help us in early diagnosis and reducing the casualties of this disease. However, further studies for finding a good solution to early diagnosis require a better understanding of the mechanism of action of this virus. In this review, we review the biochemical and immunological biomarkers used for laboratory diagnosis of SARS-CoV-2 (COVID -19).

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A contemporary review on pathogenesis and immunity of COVID-19 infection

Cited by 41 publications

References 92 publications

Early use of non-steroidal anti-inflammatory drugs in COVID-19 might reverse pathogenesis, prevent complications and improve clinical outcomes

Early use of non-steroidal anti-inflammatory drugs in COVID-19 might reverse pathogenesis, prevent complications and improve clinical outcomes

The use of positive end expiratory pressure in patients affected by COVID-19: Time to reconsider the relation between morphology and physiology

A Review on Biochemical and Immunological Biomarkers used for Laboratory Diagnosis of SARS-CoV-2 (COVID -19)

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