A Conspectus of Research on Copper Metabolism and Requirements of Man

Alterações metabólicas e funcionais do cobre em diabetes mellitus

“…Os tecidos que apresentam maiores concentrações de cobre são fígado, cérebro, baço, osso e músculo esquelético; sendo o fígado e o baço considerados órgãos de reserva (Mason, 1979), cujas concentrações observadas têm sido inversamente proporcionais à idade (Williams, 1983).…”

“…Se a excreção biliar não funcionar regularmente, pode desencadear uma toxicidade hepática de cobre, como no caso da doença de Wilson e cirrose hepática (Mason, 1979).…”

Cyclopentanone Thiosemicarbazone, a New Complexing Agent for Copper Determination in Biological Samples by Adsorptive Stripping Voltammetry

“…The main physiological processes in which copper participates are the formation of blood and the utilization of iron in hemoglobin synthesis, the synthesis and cross-linking of elastin and collagen in the aorta and major blood vessels, etc. Various disorders, like nephritic syndrome, 2 copper intoxication 3 and burn injuries 4 have been associated with higher concentrations of copper in urine. In general, the determination of increased levels of copper poses no great analytical problems, and a number of colorimetric techniques have been successfully applied.…”

Changes Acute Phase Proteins by Radiation Treatment

“…Acute phase reacting proteins are affected by aseptic or infectious inflammatory reactions (2)(3)(4)(5)(6)(7)(8). During these reactions, the synthesis of ferritin in the liver is enhanced.…”

“…S-ceruloplasmin is increased in various malignant tumors, above all in smoking- related cancers. In some patients, a rise of serum ceruloplasmin may be observed years before the diagnosis of cancer (7,8). The high levels of ceruloplasmin, after resection of the tumor, may be interpreted as residual cancer or as a protection against a previous cancer by its antioxidant activity.…”