A conserved membrane protein negatively regulates Mce1 complexes in mycobacteria
Yushu Chen,
Yuchun Wang,
Shu-Sin Chng
Abstract:Tuberculosis continues to pose a serious threat to global health. Mycobacterium tuberculosis, the causative agent of tuberculosis, is an intracellular pathogen that relies on various mechanisms to survive and persist within the host. Among their many virulence factors, mycobacteria encode Mce systems. Some of these systems are implicated in lipid uptake, but the molecular basis for Mce function(s) is poorly understood. To gain insights into the composition and architecture of Mce systems, we characterized the … Show more
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