2001
DOI: 10.1126/science.1066373 View full text |Buy / Rent full text
|
|

Abstract: Mammalian cells respond to changes in oxygen availability through a conserved pathway that is regulated by the hypoxia-inducible factor (HIF). The alpha subunit of HIF is targeted for degradation under normoxic conditions by a ubiquitin-ligase complex that recognizes a hydroxylated proline residue in HIF. We identified a conserved family of HIF prolyl hydoxylase (HPH) enzymes that appear to be responsible for this posttranslational modification. In cultured mammalian cells, inappropriate accumulation of HIF ca… Show more

Help me understand this report

Search citation statements

Order By: Relevance
0
0
0
0
0
12
1,642
0
13

Publication Types

Select...

Relationship

0
0

Authors

Journals