A connectomics approach combining structural and effective connectivity assessed by intracranial electrical stimulation

Donos, Cristian; Mălîia, Mihai Dragoş; Mı̂ndruță, Ioana; Popa, Irina; Ene, Mirela; Bălănescu, Bogdan; Ciurea, Ana; Barborică, Andrei

doi:10.1016/j.neuroimage.2016.02.054

Cited by 49 publications

(47 citation statements)

References 63 publications

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“…Stimulation 3 (patient reports that the contralateral upper limb becomes heavier) is an example of how the pI’ decouples from the DLPFC’ (Figure c,d). Since it has been previously proven that the cingulate and insular cortex are connected (Donos, Mălîia, et al, ), we could hypothesize that HFS of the CC induced a functional disconnection of the dominant pI (Figure ) which is a hub for the integration of multisensory modalities (Rodgers, Benison, Klein, & Barth, ; Zu Eulenburg et al, ). In addition, posterior dominant insula has been shown to be part of the network involved in bodily self‐consciousness illusions, namely heautoscopy, an unstable representation of self‐identification, self‐location and the first‐person perspective (Heydrich & Blanke, ).…”

Section: Discussionmentioning

confidence: 87%

“…Therefore, functional mapping of the cortex was systematically reviewed using direct electrical high frequency stimulation of the brain delivered at a rate of 50 Hz (Figure c). Bipolar stimulations were performed through pairs of adjacent contacts using a programmable clinical stimulator (Guideline4000LP+, FHC, Bowdoin, ME) in Bucharest and Osirix Cortical Stimulator (Emmendingen, Germany) in Strasbourg with a square, biphasic, 1 ms width pulse for 5 s. In addition, in a subset of patients, resting‐state connectivity was calculated based on cortico‐cortical evoked potentials elicited by single‐pulse electrical stimulation (Supporting Information S1) using the methodology presented in detail in Donos et al () and Donos, Mîndruţă et al ().…”

Section: Methodsmentioning

confidence: 99%

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Illusory own body perceptions mapped in the cingulate cortex—An intracranial stimulation study

Popa

Barborică

Scholly

et al. 2019

Human Brain Mapping

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Body awareness is the result of sensory integration in the posterior parietal cortex; however, other brain structures are part of this process. Our goal is to determine how the cingulate cortex is involved in the representation of our body. We retrospectively selected patients with drug‐resistant epilepsy, explored by stereo‐electroencephalography, that had the cingulate cortex sampled outside the epileptogenic zone. The clinical effects of high‐frequency electrical stimulation were reviewed and only those sites that elicited changes related to body perception were included. Connectivity of the cingulate cortex and other cortical structures was assessed using the h2 coefficient, following a nonlinear regression analysis of the broadband EEG signal. Poststimulation changes in connectivity were compared between two sets of stimulations eliciting or not eliciting symptoms related to body awareness (interest and control groups). We included 17 stimulations from 12 patients that reported different types of body perception changes such as sensation of being pushed toward right/left/up, one limb becoming heavier/lighter, illusory sensation of movement, sensation of pressure, sensation of floating or detachment of one hemi‐body. High‐frequency stimulation in the cingulate cortex (1 anterior, 15 middle, 1 posterior part) elicits body perception changes, associated with a decreased connectivity of the dominant posterior insula and increased coupling between other structures, located particularly in the nondominant hemisphere.

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Section: Discussionmentioning

confidence: 87%

Section: Methodsmentioning

confidence: 99%

Illusory own body perceptions mapped in the cingulate cortex—An intracranial stimulation study

Popa

Barborică

Scholly

et al. 2019

Human Brain Mapping

Self Cite

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show abstract

“…A potential source of artifacts in our data could emerge from the artifact removal procedure used to eliminate undesirable noise tied to the electrical pulses. This method, which has been already used and validated in studies analyzing evoked activity induced by single intracranial electrical pulses344748 consists in the interpolation of the removed artifacted period using a third degree spline. We tested the ability of this approach to remove any contributions from oscillatory activity at the frequency of interest (50 Hz) originated from a non-physiological source, by conducting a series of statistical control analysis using real and artificially artifacted datasets.…”

Section: Discussionmentioning

confidence: 99%

Local entrainment of oscillatory activity induced by direct brain stimulation in humans

Amengual

Vernet

Adam

et al. 2017

Sci Rep

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In a quest for direct evidence of oscillation entrainment, we analyzed intracerebral electroencephalographic recordings obtained during intracranial electrical stimulation in a cohort of three medication-resistant epilepsy patients tested pre-surgically. Spectral analyses of non-epileptogenic cerebral sites stimulated directly with high frequency electrical bursts yielded episodic local enhancements of frequency-specific rhythmic activity, phase-locked to each individual pulse. These outcomes reveal an entrainment of physiological oscillatory activity within a frequency band dictated by the rhythm of the stimulation source. Our results support future uses of rhythmic stimulation to elucidate the causal contributions of synchrony to specific aspects of human cognition and to further develop the therapeutic manipulation of dysfunctional rhythmic activity subtending the symptoms of some neuropsychiatric conditions.

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“…Although limited to rare opportunities in patients with intractable partial epilepsy who undergo invasive evaluation, CCEP can provide one of the most solid connectivity maps by taking advantage of its ability to probe effective connectivity with high spatiotemporal resolution [30, 45] [15, 46]. The CCEP connectivity map can be used as a reference for non-invasive connectivity studies.…”

Section: Ccep Methodologymentioning

confidence: 99%

Single pulse electrical stimulation to probe functional and pathological connectivity in epilepsy

Matsumoto

Kunieda

Nair

2017

Seizure

145

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In the last decade, single pulse electrical stimulation (SPES) has been used as an investigational tool in the field of epilepsy surgery. Direct cortical stimulation applied at a frequency of ∼1 Hz can probe cortico-cortical connections by averaging electrocorticogram time-lock to the stimuli (2 x 20–30 trials). These evoked potentials that emanate from adjacent and remote cortices have been termed cortico-cortical evoked potentials (CCEPs). Although limited to patients undergoing invasive presurgical evaluations with intracranial electrodes, CCEP provides a novel way to explore inter-areal connectivity in vivo in the living human brain to probe functional brain networks such as language and cognitive motor networks. In addition to its impact on systems neuroscience, this method, in combination with 50 Hz electrical cortical stimulation, could contribute clinically to map the functional brain systems by tracking the cortico-cortical connections among the functional cortical regions in each individual patient. This approach may help identify the normal cortico-cortical network within pathology as well as reveal connections that might arise from neural plasticity. Because of its high practicality, it has been recently applied for intraoperative monitoring of the functional brain networks for patients with brain tumor. With regard to epilepsy, SPES has been used for the two major purposes, one to probe cortical excitability of the focus, namely, epileptogenicity, and the other to probe seizure networks. Both early (i.e., CCEP) and delayed responses, and probably their high frequency oscillation counterparts, are regarded as a surrogate marker of epileptogenicity. With regards to its impact on the human brain connectivity map, worldwide collaboration is warranted to establish the standardized CCEP connectivity map as a solid reference for non-invasive connectome researches.

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A connectomics approach combining structural and effective connectivity assessed by intracranial electrical stimulation

Cited by 49 publications

References 63 publications

Illusory own body perceptions mapped in the cingulate cortex—An intracranial stimulation study

Illusory own body perceptions mapped in the cingulate cortex—An intracranial stimulation study

Local entrainment of oscillatory activity induced by direct brain stimulation in humans

Single pulse electrical stimulation to probe functional and pathological connectivity in epilepsy

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