A Connectomic Atlas of the Human Cerebrum—Chapter 11: Tractographic Description of the Inferior Longitudinal Fasciculus

Sali, Goksel; Briggs, Robert G.; Conner, Andrew K.; Rahimi, Meherzad; Baker, Cordell M; Burks, Joshua D.; Glenn, Chad A.; Battiste, James; Sughrue, Michael E.

doi:10.1093/ons/opy265

Cited by 39 publications

(12 citation statements)

References 27 publications

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“…Damage to it is associated with deficits in object recognition, including prosopagnosia. 64 The cingulum interconnects medial parts of the frontal, parietal, and temporal lobes. In addition to its limbic role in emotional processing, it connects the anterior cingulate and posterior cingulate cortices, a vital function for the default mode network.…”

Section: Discussionmentioning

confidence: 99%

Tractography and the connectome in neurosurgical treatment of gliomas: the premise, the progress, and the potential

Henderson

Abdullah

Verma

et al. 2020

Neurosurgical Focus

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The ability of diffusion tensor MRI to detect the preferential diffusion of water in cerebral white matter tracts enables neurosurgeons to noninvasively visualize the relationship of lesions to functional neural pathways. Although viewed as a research tool in its infancy, diffusion tractography has evolved into a neurosurgical tool with applications in glioma surgery that are enhanced by evolutions in crossing fiber visualization, edema correction, and automated tract identification. In this paper the current literature supporting the use of tractography in brain tumor surgery is summarized, highlighting important clinical studies on the application of diffusion tensor imaging (DTI) for preoperative planning of glioma resection, and risk assessment to analyze postoperative outcomes. The key methods of tractography in current practice and crucial white matter fiber bundles are summarized. After a review of the physical basis of DTI and post-DTI tractography, the authors discuss the methodologies with which to adapt DT image processing for surgical planning, as well as the potential of connectomic imaging to facilitate a network approach to oncofunctional optimization in glioma surgery.

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Section: Discussionmentioning

confidence: 99%

Tractography and the connectome in neurosurgical treatment of gliomas: the premise, the progress, and the potential

Henderson

Abdullah

Verma

et al. 2020

Neurosurgical Focus

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“…The superior fasciculus are involved in language, attention, and emotion [Conner et al, 2018], while the inferior fasciculus function in emotional regulation and semantic and visual processing [Herbet et al, 2018;Sali et al, 2018]. Poor development of the left superior longitudinal fasciculus has been described in autism and language disorders [Verhoeven et al, 2012;Aoki et al, 2013;Boets et al, 2018;Verly et al, 2019].…”

Section: Discussionmentioning

confidence: 99%

Neuroimaging Findings in Patients with EBF3 Mutations: Report of Two Cases

et al. 2021

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Early B cell factor 3 (EBF3) is a transcription factor involved in brain development. Heterozygous, loss-of-function mutations in EBF3 have been reported in an autosomal dominant neurodevelopmental syndrome characterized by hypotonia, ataxia, and developmental delay (sometimes described as “HADD”s). We report 2 unrelated cases with novel de novo EBF3 mutations: c.455G>T (p.Arg152Leu) and c.962dup (p.Tyr321*) to expand the genotype/phenotype correlations of this disorder; clinical, neuropsychological, and MRI studies were used to define the phenotype. IQ was in the normal range and diffusion tensor imaging revealed asymmetric alterations of the longitudinal fasciculus in both cases. Our results demonstrate that EBF3 mutations can underlie neurodevelopmental disorders without intellectual disability. Long tract abnormalities have not been previously recognized and suggest that they may be an unrecognized and characteristic feature in this syndrome.

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“…Specifically, the ILF carries visual information to the temporal pole, which projects onward to area 45 via the uncinate fasciculus. 38,44,45 3) The middle temporal gyrus (MTG) model: the semantic areas in the posterior MTG and superior temporal sulcus (STS) send fibers anteriorly to the temporal pole, which connects to area 45 via the uncinate. 7 In the following list, we summarize our own findings on this topic using the HCP data and suggest that two or even all three of these models may be simultaneously true to varying degrees.…”

Section: The Elusive Anatomy Of the Ventral Language Streammentioning

confidence: 99%

“…5C) or the ventral stream classically involved in object identification. 45 However, there are a few problems with hypothesizing that the ILF carries information about object identity to the temporal pole. First, the temporal gyrus dorsal area, which is the majority of the temporal FIG.…”

Section: The Elusive Anatomy Of the Ventral Language Streammentioning

confidence: 99%

“…Furthermore, our work suggests that the connections seem to be dominated with visual processing steps too early to meaningfully be carrying this information to a higher cognitive area such as 45. 40,45 Early visual areas such as V1 are mainly concerned with processes such as line orientation and centersurround inhibition, 50 which is not intuitively useful when naming objects. However, we know that visual processing is extremely reliant on top-down selection and modulation; thus, we should not exclude the possibility that the IFOF and/or ILF are important parts of this and that interrupting them could have consequences for language processing.…”

Section: The Elusive Anatomy Of the Ventral Language Streammentioning

confidence: 99%

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The cortical organization of language: distilling human connectome insights for supratentorial neurosurgery

Poologaindran

Lowe

Sughrue

2021

Journal of Neurosurgery

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Connectomics is the production and study of detailed “connection” maps within the nervous system. With unprecedented advances in imaging and high-performance computing, the construction of individualized connectomes for routine neurosurgical use is on the horizon. Multiple projects, including the Human Connectome Project (HCP), have unraveled new and exciting data describing the functional and structural connectivity of the brain. However, the abstraction from much of these data to clinical relevance remains elusive. In the context of preserving neurological function after supratentorial surgery, abstracting surgically salient points from the vast computational data in connectomics is of paramount importance. Herein, the authors discuss four interesting observations from the HCP data that have surgical relevance, with an emphasis on the cortical organization of language: 1) the existence of a motor speech area outside of Broca’s area, 2) the eloquence of the frontal aslant tract, 3) the explanation of the medial frontal cognitive control networks, and 4) the establishment of the second ventral stream of language processing. From these connectome observations, the authors discuss the anatomical basis of their insights as well as relevant clinical applications. Together, these observations provide a firm platform for neurosurgeons to advance their knowledge of the cortical networks involved in language and to ultimately improve surgical outcomes. It is hoped that this report encourages neurosurgeons to explore new vistas in connectome-based neurosurgery.

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A Connectomic Atlas of the Human Cerebrum—Chapter 11: Tractographic Description of the Inferior Longitudinal Fasciculus

Cited by 39 publications

References 27 publications

Tractography and the connectome in neurosurgical treatment of gliomas: the premise, the progress, and the potential

Tractography and the connectome in neurosurgical treatment of gliomas: the premise, the progress, and the potential

Neuroimaging Findings in Patients with <b><i>EBF3</i></b> Mutations: Report of Two Cases

The cortical organization of language: distilling human connectome insights for supratentorial neurosurgery

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