A Connectomic Atlas of the Human Cerebrum—Chapter 13: Tractographic Description of the Inferior Fronto-Occipital Fasciculus

Conner, Andrew K.; Briggs, Robert G.; Sali, Goksel; Rahimi, Meherzad; Baker, Cordell M; Burks, Joshua D.; Glenn, Chad A.; Battiste, James; Sughrue, Michael E.

doi:10.1093/ons/opy267

Cited by 74 publications

(62 citation statements)

References 25 publications

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“…The principal finding was a bilateral reduction in FA of the IFOF in two independent groups of HCMV+ versus HCMV− adults with MDD but no corresponding significant HCMV effect in HCs. The IFOF is a large white matter tract that connects the occipital lobe to the inferior frontal lobe (particularly the orbitofrontal cortex) via the insula and the posterolateral temporal lobe [83]. The IFOF is involved in semantic language processing [84] but perhaps more relevant to psychiatry, connects the "salience network" to the "executive network", and therefore plays a role in integrating emotional and cognitive stimuli to facilitate goal-oriented behavior [83,85].…”

Section: Discussionmentioning

confidence: 99%

“…The IFOF is a large white matter tract that connects the occipital lobe to the inferior frontal lobe (particularly the orbitofrontal cortex) via the insula and the posterolateral temporal lobe [83]. The IFOF is involved in semantic language processing [84] but perhaps more relevant to psychiatry, connects the "salience network" to the "executive network", and therefore plays a role in integrating emotional and cognitive stimuli to facilitate goal-oriented behavior [83,85]. Reduced FA of the IFOF has been widely reported in MDD populations [86][87][88][89][90][91][92][93][94][95][96] but appears to be a non-specific finding, also being reported in bipolar disorder (BD) [89,97,98], outpatients with subsyndromal affective and psychotic symptoms [99], schizophrenia [100], Parkinson's disease with psychosis [101], and individuals with a history of childhood maltreatment [102].…”

Section: Discussionmentioning

confidence: 99%

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Replicable association between human cytomegalovirus infection and reduced white matter fractional anisotropy in major depressive disorder

Zheng

Bergamino

Ford

et al. 2021

Neuropsychopharmacol.

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Major depressive disorder (MDD) is associated with reductions in white matter microstructural integrity as measured by fractional anisotropy (FA), an index derived from diffusion tensor imaging (DTI). The neurotropic herpesvirus, human cytomegalovirus (HCMV), is a major cause of white matter pathology in immunosuppressed populations but its relationship with FA has never been tested in MDD despite the presence of inflammation and weakened antiviral immunity in a subset of depressed patients. We tested the relationship between FA and HCMV infection in two independent samples consisting of 176 individuals with MDD and 44 healthy controls (HC) (Discovery sample) and 88 participants with MDD and 48 HCs (Replication sample). Equal numbers of HCMV positive (HCMV+) and HCMV negative (HCMV−) groups within each sample were balanced on ten different clinical/demographic variables using propensity score matching. Anti-HCMV IgG antibodies were measured using a solid-phase ELISA. In the Discovery sample, significantly lower FA was observed in the right inferior fronto-occipital fasciculus (IFOF) in HCMV+ participants with MDD compared to HCMV− participants with MDD (cluster size 1316 mm3; pFWE < 0.05, d = −0.58). This association was confirmed in the replication sample by extracting the mean FA from this exact cluster and applying the identical statistical model (p < 0.05, d = −0.45). There was no significant effect of diagnosis or interaction between diagnosis and HCMV in either sample. The effect of chronic HCMV infection on white matter integrity may—in at-risk individuals—contribute to the psychopathology of depression. These findings may provide a novel target of intervention for a subgroup of patients with MDD.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Replicable association between human cytomegalovirus infection and reduced white matter fractional anisotropy in major depressive disorder

Zheng

Bergamino

Ford

et al. 2021

Neuropsychopharmacol.

View full text Add to dashboard Cite

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“…The former connects the occipital cortex, temporal-basal areas and superior parietal to the frontal lobe and passes the insula region (Martino et al, 2010;Wu et al, 2016). Functionally, its role has been previously associated with semantic language processing and transmission, as well as goal oriented behavior (Conner et al, 2018). The latter, which shows functional and anatomical overlaps with the IFOF (Ashtari, 2012), connects the occipital and temporal-occipital areas to the anterior temporal areas.…”

Section: Discussionmentioning

confidence: 94%

Pinpointing Neural Correlates of Attachment in Poly-Drug Use: A Diffusion Tensor Imaging Study

et al. 2020

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An increasing amount of evidence indicates the significance of attachment in the etiology of poly-drug use disorder (PUD). The aim of this study was to investigate associations between PUD and adult attachment in particular, with a focus on white matter (WM) fiber tract integrity. For this purpose, we selected several regions-ofinterest based on previous findings which were examined for their role in PUD and estimated whole-brain associations between adult attachment and WM integrity. A total sample of 144 right-handed males were investigated (Age: M = 27; SD = 4.66). This included a group of patients diagnosed with PUD (n = 70) and a group of healthy controls (HC; n = 74). The Adult Attachment Scales (AAS) was applied to assess attachment attitudes in participants. Diffusion Tensor Imaging was used to investigate differences in WM integrity. The findings suggest substantially less attachment security in PUD patients compared to HC. Furthermore, PUD patients exhibited reduced integrity in WM fiber tracts, most pronounced in the bilateral corticospinal tract, the frontooccipital fasciculus, and the right inferior longitudinal fasciculus. However, these results were not controlled for comorbid depressiveness. With regard to associations between adult attachment and WM integrity, the results for PUD patients indicate a negative relationship between "Comfort with Closeness" and the structural integrity of a cluster comprising parts of the right anterior thalamic radiation, the inferior fronto-occipital fasciculus and the uncinate fasciculus. Despite being limited by the cross-sectional design of this study, the results emphasize the significance of attachment in PUD etiology, both at a behavioral and a neurological level. Largely in line with previous research, the findings revealed tentative links between adult attachment and WM fiber tracts related to cognitive and affective functions in PUD patients.

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“…It probably facilitates goal-oriented behavior because it is involved in the salience and executive networks. 22 The uncinate fasciculus (UF) connects the temporal pole, uncus, parahippocampal gyrus, and amygdala with the lateral orbitofrontal cortex, cingulum, and frontal pole. It has general associations in semantic processing, episodic memory, and emotional processing.…”

Section: Discussionmentioning

confidence: 99%

Tractography and the connectome in neurosurgical treatment of gliomas: the premise, the progress, and the potential

Henderson

Abdullah

Verma

et al. 2020

Neurosurgical Focus

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The ability of diffusion tensor MRI to detect the preferential diffusion of water in cerebral white matter tracts enables neurosurgeons to noninvasively visualize the relationship of lesions to functional neural pathways. Although viewed as a research tool in its infancy, diffusion tractography has evolved into a neurosurgical tool with applications in glioma surgery that are enhanced by evolutions in crossing fiber visualization, edema correction, and automated tract identification. In this paper the current literature supporting the use of tractography in brain tumor surgery is summarized, highlighting important clinical studies on the application of diffusion tensor imaging (DTI) for preoperative planning of glioma resection, and risk assessment to analyze postoperative outcomes. The key methods of tractography in current practice and crucial white matter fiber bundles are summarized. After a review of the physical basis of DTI and post-DTI tractography, the authors discuss the methodologies with which to adapt DT image processing for surgical planning, as well as the potential of connectomic imaging to facilitate a network approach to oncofunctional optimization in glioma surgery.

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A Connectomic Atlas of the Human Cerebrum—Chapter 13: Tractographic Description of the Inferior Fronto-Occipital Fasciculus

Cited by 74 publications

References 25 publications

Replicable association between human cytomegalovirus infection and reduced white matter fractional anisotropy in major depressive disorder

Replicable association between human cytomegalovirus infection and reduced white matter fractional anisotropy in major depressive disorder

Pinpointing Neural Correlates of Attachment in Poly-Drug Use: A Diffusion Tensor Imaging Study

Tractography and the connectome in neurosurgical treatment of gliomas: the premise, the progress, and the potential

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