A Connectomic Atlas of the Human Cerebrum—Chapter 10: Tractographic Description of the Superior Longitudinal Fasciculus

Conner, Andrew K.; Briggs, Robert G.; Rahimi, Meherzad; Sali, Goksel; Baker, Cordell M; Burks, Joshua D.; Glenn, Chad A.; Battiste, James; Sughrue, Michael E.

doi:10.1093/ons/opy264

Cited by 23 publications

(15 citation statements)

References 31 publications

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“…The SLF generally subserves a wide variety of functions related to language, attention, memory, emotion, and visuospatial function; many studies have pointed to its function in visuospatial awareness, as well as attentional selection of sensory content. 21,43,44 Our findings are partly in accordance with those of others that have found neurodevelopmental effects linked with unilaterally compromised lSLF maturation during adolescence. 45 Thus, ADHD symptom persistence may influence higher unilateral SLF integrity as a person develops from early adolescence to young adulthood.…”

Section: Discussionsupporting

confidence: 92%

Associations between ADHD symptom remission and white matter microstructure: a longitudinal analysis

Leenders¹,

Damatac²,

Soheili-Nezhad³

et al. 2020

Preprint

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ObjectiveAttention-deficit hyperactivity disorder (ADHD) is associated with white matter (WM) microstructure. Our objective was to investigate how WM microstructure is longitudinally related to symptom remission in adolescents and young adults with ADHD.MethodWe obtained diffusion-weighted imaging (DWI) data from 99 participants at two time points (mean age baseline: 16.91 years, mean age follow-up: 20.57 years). We used voxel-wise Tract-Based Spatial Statistics (TBSS) with permutation-based inference to investigate associations of inattention (IA) and hyperactivity-impulsivity (HI) symptom change with fractional anisotropy (FA) at baseline, follow-up, and change difference between time points.ResultsRemission of combined HI and IA symptoms was significantly associated with reduced FA at follow-up in the left superior longitudinal fasciculus and the left corticospinal tract (CST) (PFWE=0.038 and PFWE=0.044, respectively), mainly driven by an association between HI remission and follow-up CST FA (PFWE=0.049). There was no significant association of combined symptom remission with FA at baseline or with changes in FA between the two assessments.ConclusionIn this longitudinal DWI study of ADHD using dimensional symptom scores, we show that greater symptom remission is associated with lower follow-up FA in specific WM tracts. Altered FA thus may appear to follow, rather than precede, changes in symptom remission. Our findings indicate divergent WM developmental trajectories between individuals with persistent and remittent ADHD, and support the role of prefrontal and sensorimotor tracts in the remission of ADHD.

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Section: Discussionsupporting

confidence: 92%

Associations between ADHD symptom remission and white matter microstructure: a longitudinal analysis

Leenders¹,

Damatac²,

Soheili-Nezhad³

et al. 2020

Preprint

View full text Add to dashboard Cite

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“…First, parcellating the brain of structurally abnormal patients has long been a source of variability in the data, especially in the presence of brain atrophy. By using a machine learning approach based on structural connectivity patterns, we hold at least one variable (voxel identity in a parcellation) relatively constant, as the connectivity pattern should remain similar for a parcellation across brains (41,(47)(48)(49). Further, while the connectome has seemingly infinite interindividual variability, we hypothesize that clinically relevant phenotypes we are interested in at this early stage are less likely to result from the loss of rare individual variants in connectivity, and instead result from more constant interindividual connections.…”

Section: Discussionmentioning

confidence: 99%

Application of Structural and Functional Connectome Mismatch for Classification and Individualized Therapy in Alzheimer Disease

Ren

Zhu

et al. 2020

Front. Public Health

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While machine learning approaches to analyzing Alzheimer disease connectome neuroimaging data have been studied, many have limited ability to provide insight in individual patterns of disease and lack the ability to provide actionable information about where in the brain a specific patient's disease is located. We studied a cohort of patients with Alzheimer disease who underwent resting state functional magnetic resonance imaging and diffusion tractography imaging. These images were processed, and a structural and functional connectivity matrix was generated using the HCP cortical and subcortical atlas. By generating a machine learning model, individual-level structural and functional anomalies detection and characterization were explored in this study. Our study found that structural disease burden in Alzheimer's patients is mainly focused in the subcortical structures and the Default mode network (DMN). Interestingly, functional anomalies were less consistent between individuals and less common in general in these patients. More intriguing was that some structural anomalies were noted in all patients in the study, namely a reduction in fibers involving parcellations in the right anterior cingulate. Alternately, the functional consequences of connectivity loss were cortical and variable. Integrated structural/functional connectomics might provide a useful tool for assessing AD progression, while few concerns have been made for analyzing the mismatch between these two. We performed a preliminary exploration into a set of Alzheimer disease data, intending to improve a personalized approach to understanding individual connectomes in an actionable manner. Specifically, we found that there were consistent patterns of white matter fiber loss, mainly focused around the DMN and deep subcortical structures, which were present in nearly all patients with clinical AD. Functional magnetic resonance imaging shows abnormal functional connectivity different within the patients, which may be used as the individual target for further therapeutic strategies making, like non-invasive stimulation technology.

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“…The SLF has 4 portions: SLF I connects the superior parietal lobule and supplemental motor areas of the superior frontal gyrus; SLF II connects the inferior parietal lobule and the dorsolateral prefrontal cortex; SLF III connects the inferior parietal lobule through parietal and frontal opercula to the inferior frontal gyrus; and AF connects the frontal operculum to the temporal operculum. 21 In broad terms the inferior longitudinal fasciculus (ILF) connects the occipital lobe to the temporal lobe. Damage to it is associated with deficits in object recognition, including prosopagnosia.…”

Section: Discussionmentioning

confidence: 99%

Tractography and the connectome in neurosurgical treatment of gliomas: the premise, the progress, and the potential

Henderson

Abdullah

Verma

et al. 2020

Neurosurgical Focus

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The ability of diffusion tensor MRI to detect the preferential diffusion of water in cerebral white matter tracts enables neurosurgeons to noninvasively visualize the relationship of lesions to functional neural pathways. Although viewed as a research tool in its infancy, diffusion tractography has evolved into a neurosurgical tool with applications in glioma surgery that are enhanced by evolutions in crossing fiber visualization, edema correction, and automated tract identification. In this paper the current literature supporting the use of tractography in brain tumor surgery is summarized, highlighting important clinical studies on the application of diffusion tensor imaging (DTI) for preoperative planning of glioma resection, and risk assessment to analyze postoperative outcomes. The key methods of tractography in current practice and crucial white matter fiber bundles are summarized. After a review of the physical basis of DTI and post-DTI tractography, the authors discuss the methodologies with which to adapt DT image processing for surgical planning, as well as the potential of connectomic imaging to facilitate a network approach to oncofunctional optimization in glioma surgery.

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A Connectomic Atlas of the Human Cerebrum—Chapter 10: Tractographic Description of the Superior Longitudinal Fasciculus

Cited by 23 publications

References 31 publications

Associations between ADHD symptom remission and white matter microstructure: a longitudinal analysis

Associations between ADHD symptom remission and white matter microstructure: a longitudinal analysis

Application of Structural and Functional Connectome Mismatch for Classification and Individualized Therapy in Alzheimer Disease

Tractography and the connectome in neurosurgical treatment of gliomas: the premise, the progress, and the potential

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