A conjugate addition-dipolar cycloaddition approach towards the synthesis of various alkaloids

Abstract

The key element for the synthesis of several alkaloid skeletons consists of a conjugate additiondipolar cycloaddition of 2,3-bis(phenylsulfonyl)-1,3-butadiene with an appropriate oxime. The resulting cycloadducts are cleaved reductively to provide azapolycyclic scaffolds with strategically placed functionality for further manipulation to the target compounds.