A Confiscation Case Involving a Novel Barbiturate Designer Drug

Ohta, Hikoto; Suzuki, Yasuhito; Sugita, Ryusuke; Suzuki, Shigeo; Ogasawara, Kunio

doi:10.1080/00085030.2000.10757506

Cited by 2 publications

(1 citation statement)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Analyses of confiscation samples are most commonly accomplished by gas chromatography coupled to mass spectrometry (GC-MS) 1,2,8,11 and liquid chromatography interfaced to mass spectrometry (LC-MS). [1][2][3]11,12 Other less commonly used analytical techniques include Fourier-transform infrared (FTIR)-attenuated total reflectance spectroscopy, 13 desorption atmospheric pressure photoionization (DAPPI) coupled to MS, 14,15 desorption electrospray ionization (DESI) interfaced to MS, 16,17 matrix-assisted laser desorption ionization-time of flight mass spectrometry, 18 voltammetry, 19 capillary electrophoresis, 20 nuclear magnetic resonance spectroscopy, 11,21 and single crystal X-ray diffraction. 22 Although FTIR, voltammetry, capillary electrophoresis, and X-ray diffraction all provide useful information for identification of known compounds, the ability of MS to generate information on molecular weight and fragment ions makes it the technique of choice for identification of unknown compounds in confiscated samples.…”

Section: Introductionmentioning

confidence: 99%

Automated identification of unknown doping agents in confiscation samples by flow‐injection mass spectrometry and mass spectral library searches

Guan

Fay

Adreance

et al. 2023

Drug Testing and Analysis

View full text Add to dashboard Cite

Rapid and accurate identification of unknown compounds within suspicious samples confiscated for sports doping control and law enforcement drug testing is critical, but such analyses are often conducted manually and can be time-consuming. Here, we report a methodology for automated identification of unknown substances in confiscation samples by rapid automatic flow-injection analysis on a liquid chromatography coupled to high-resolution mass spectrometry system and identifying unknown compounds with Compound Discoverer software. The developed methodology was validated by comparing the automated identification results with those obtained from manual syringe-infusion experiments and manual tandem mass spectral library searches. The automated methodology resulted in far higher throughput and remarkably shorter turnaround time for analysis when compared with manual procedures and, in most cases, yielded more compounds. As this is the first such report to the authors' knowledge, this methodology may potentially transform analysis of confiscated samples in sports doping control and law enforcement drug testing.

show abstract