“…Analyses of confiscation samples are most commonly accomplished by gas chromatography coupled to mass spectrometry (GC-MS) 1,2,8,11 and liquid chromatography interfaced to mass spectrometry (LC-MS). [1][2][3]11,12 Other less commonly used analytical techniques include Fourier-transform infrared (FTIR)-attenuated total reflectance spectroscopy, 13 desorption atmospheric pressure photoionization (DAPPI) coupled to MS, 14,15 desorption electrospray ionization (DESI) interfaced to MS, 16,17 matrix-assisted laser desorption ionization-time of flight mass spectrometry, 18 voltammetry, 19 capillary electrophoresis, 20 nuclear magnetic resonance spectroscopy, 11,21 and single crystal X-ray diffraction. 22 Although FTIR, voltammetry, capillary electrophoresis, and X-ray diffraction all provide useful information for identification of known compounds, the ability of MS to generate information on molecular weight and fragment ions makes it the technique of choice for identification of unknown compounds in confiscated samples.…”